Levavet 10% solution

Levavet 10% solution
Levavet 10% solution
Ingredients: Levamisole hydrochloride
Application: Transparent liquid
Type of formulation: Antiparasitic

DESCRIPTION

Transparent liquid, colorless or yellowish color.

COMPOSITION

Each1 ml contains the active ingredient:
Levamisole hydrochloride – 100 mg.

PHARMACOLOGICAL PROPERTIES

ATC vet QP52A, antitrematode, antinematode and anticestode veterinary preparations (QP52AE01, levamizol).
Levamizol hydrochloride – laevorotatory isomer, belongs to imidazothiazol group.
The mechanism of action of the preparation is that levamizol specifically inhibits the enzyme of succinatedehydrogenase, blocking the major for nematodes reaction of fumarate recovery and violates the bioenergetic processes of the body of worms.
Moreover, while researching of anthelmintic activity of levamizol it has been found that it increases the overall resistance of the organism of animals and can be used as a preparation for enhancing immunity. 
Levamizol’s immunostimulating action mechanism is the activation and proliferation of T-lymphocytes, increasing of macrophages activity, increasing of mobility and chemotaxis of neutrophils.

INDICATIONS

For treatment and prevention in cattle, sheep, goats, pigs, dogs, birds with diseases caused by:
Cattle, sheep, goats:
• gastro-intestinal nematodiases (adult and larval forms) Haemonchus spp., Ostertagia spp., Cooperia spp., Trichostrongylusspp., Nematodirus spp., Bunostomum spp., Oesophagostomum spp.;
• pulmonary nematodiases: Dictyocaulus spp.;
Pigs:
• gastrointestinal nematodiases: Ascaris suum, Strongyloides ransomi, Oesophagostomum spp;
• pulmonary nematodiases: Metastrongylus spp.
Dogs:
• Toxascaris spr., Toxocara spr., Ancylostoma spr., Uncinaria spr.
Birds:
 Ascaridia galli, Heterakis gallinarium, Capillaria spp., Singamus trachea.

DOSAGE

The preparation is injected subcutaneously once in the following doses:
cattle: 0.75 ml per 10 kg of body weight, maximum dose - 22.5 ml per body weight more than 300 kg.;
sheep, goats: 0.75 ml per 10 kg of body weight;
pigs: 0.75 ml per 10 kg of body weight;
dogs: 0.75 ml per 10 kg of body weight once orally;
poultry: orally for three consecutive days of 1 ml per 250 ml of drinking water. 
For animals weighing more than 150 kg maximum dose is 3.5 ml per each 50 kg of body weight.

CONTRAINDICATIONS

Do not use to animals with impaired liver and kidney functions.
Do not use to animals with hypersensitivity to levamizol.
Do not use to weak, exhausted and sick animals.
Do not use to piglets weighing less than10 kg.
Do not use to pregnant ruminants in the last three months of pregnancy. 
For pregnant animals the preparation is used only when it’s absolutely necessary because of the negative effect on the fetus.

PRECAUTIONS

Animals may only be slaughtered for meat after 7 days from the last treatment. Milk may be used for food after 3 days.

HOW SUPPLIED

Vials of neutral glass of 10, 20, 50, 100 ml, closed by a rubber stopper and sealed with an aluminum cover. Secondary package: cartons.

STORAGE

Dry, dark, inaccessible to children place at temperature from 10 to 25°C.
Shelf life – 2 years. 
After the first selection from the vial, the medicine should be used within 14 days, provided storage in a dark place at a temperature of 0°C to 5°C.

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