BAKTIOFUR 10%
| Ingredients: | Ceftiofur |
| Application: | Injection |
| Type of formulation: | Antibiotic |
Description
Oily suspension for injections
from white to light brown color.
Composition
1 ml of the preparation contains active substance:
free acid of crystalline сeftiofur
-100 mg.
Auxiliary substances: cottonseed oil,
triglycerides with medium length of chain.
Pharmacological properties
ATC vet classification
code QJ01 – anti-infective veterinary preparations for system application.
Сeftiofur
is a semi-synthetic antibiotic of third generation cephalosporins group. It
possesses a wide spectrum of action against gram-positive and gram-negative
bacteria (Pasteurella haemolytica
(Mannheimia spp.), Escherichia coli, Pasteurella multocida, Haemophilus somnus,
Heamophilus parasuis, Fusobacterium necrophorum and Bacteroides melaninogenicus (Porphyromonas asaccharolytica),
Arcanobacterium pyogenes, Fusobacterium necrophorum, Pasteurella
multocida, Actinobacillus
pleuropneumoniae and Streptococcus
suis). Сeftiofur inhibits (suppresses) synthesis of cell walls of bacteria,
suppressing synthesis of peptidoglycan.
Сeftiofur shows active
effect on the following pathogens which cause respiratory and other infectious
diseases in pigs: Actinobacillus
pleuropneumoniae, Pasteurella multocida, Heamophilus parasuis and Streptococcus suis.
After parenteral administration,
сeftiofur is rapidly metabolized into desferalceftiofur, active metabolite. Due
to the binding to plasma proteins, active ceftiofur metabolite is concentrated
in the site of inflammation.
Maximum concentration in blood
plasma is observed after 22 hours after administration of the preparation.
Preparation excretion from the organism occurs within 10 days after
administration. Сeftiofur is excreted from organism mostly with urine and
partially with feces.
Application
Treatment of pigs suffering from
septicemia, polyarthritis, polyserositis as well as when pulmonary organs
diseases and other infectious diseases caused by microorganisms sensitive to
ceftiofur.
Dosing
Intramuscularly
at a dose of 1 ml of the preparation for 20 kg of body mass (5 mg of сeftiofur
for kg of body mass) once to the neck area.
Prior to use a vial with the preparation should be
thoroughly shaken to homogeneous suspension obtaining and sediment
resuspension.
For
determining of a necessary dose and avoiding insufficient amount of the
preparation administration, it is necessary to accurately determine mass of
animal. Maximum volume of the preparation for administration
into one site must not exceed 4 ml.
Contra-indications
Do not apply to animals with increased sensitivity to
B-lactam antibiotics.
Do
not administer intravenously.
Warning
Slaughter of animals for
meat is permitted after 71 days after last application of the preparation.
Obtained before specified period
meat is disposed or fed to non productive animals, depending on conclusion of
veterinary medicine doctor.
Application of the
preparation should be based on pathogens sensitivity determination as well as
taking into account of local rules of antimicrobial preparations application.
Penicillins and cephalosporins can cause reactions of hypersensitivity after
injection, inhaling, ingestion or contact with skin.
Hypersensitivity to
penicillins can cause cross-reactions to сephaIosporins and on the contrary.
Allergic reactions to these substances sometimes can be severe.
When application of the preparation in accordance to the package
leaflet, side effects and complications are usually not observed. In particular
cases, formation of swelling and area of alopecia at the site of administration
of the preparation, which disappears within 56 days after administration of the
preparation are possible.
Should avoid of accidental administration of the preparation to a human. In
case of accidental injection to a human, consult a doctor immediately showing
the package leaflet or the preparation label. Working with the preparation to
people with increased sensitivity to B-lactam antibiotics is not recommended.
In case of preparation
contact with skin, rinse thoroughly with soap and water. In case of contact
with eyes rinse with pure water immediately.
Form of presentation
Vials of neutral glass (marks NS-1, NS-2, UPS-1)
closed with rubber stoppers under aluminum crimp seal of 10, 20, 50, 100 and
200 ml. Secondary package – cardboard box.
Storage
Dry, dark, out of the reach of
children place at a temperature from 5°C to 25°C.
Shelf life - 2 years from the
date of manufacture while observing the storing conditions in a closed package.
After first withdrawal from
the vial the preparation should be used within 14 days, under conditions of
storing in a dark place at a temperature from 0 °С to 8 °С.
For applications in veterinary medicine!