Eymerisan 88 (granular powder for oral administration)

Eymerisan 88 (granular powder for oral administration)
Ingredients: Monensin sodiumm, Nicarbazin
Application: oral
Type of formulation: COCCIDIOSTATIC

Description

Granular green-brown powder.

Composition

1 g contains active ingredients:

Monensin sodium – 80 mg;

Nicarbazin – 80 mg.

Additive agents: amylum, calcium carbonate.

Pharmacological Properties

ATCvet QP51, antiprotozoal veterinary products (QP51АН03, monensin, QP51АН04, nicarbazin)

       EYMERISAN 88 is a combined medicinal product containing monensin sodium and nicarbazin.

 The combination of active ingredients provides effective antieimerial effect.

Monensin sodium is polyether ionophore antibiotic. Nicarbazin is a synthetic anticoccidial agent that includes complex of components: 4,4'- dinitrodifenil carbamide (DNC) and 2-hydro-4,6- dimetilpirimidin (HDP) that inhibits energetic metabolism in the parasite organism.

      Monensin and nicarbazin have a wide spectrum of anticoccidial effect, effective against eimeria (Eimeria tenella, E. acervulina, E. necatrix, E. maxima, E. mivati, E. brunetty, E. mitis, E. praecox, E. adenoides, E. мeleagrimitis, E. gallopavonis) parasitizing poultry. Monensin effect upon eimeria is conditioned ​​ by the ability to form lipophilic complexes with alkali and alkali earth metal ions and to carry them over the eimeria cell wall that leads to disturbance of osmotic balance and death of protozoa. Nicarbazin is a synthetic complex of components: 4,4'- dinitrodifenil carbamide (DNC) and 2-hydro-4,6- dimetilpirimidin (HDP). DNC and not HDP has anticoccidial effect upon eimeria (Eimeria). Complex of DNC and HDP in digestive tract leads to formation of far smaller DNC crystals in comparison with water insoluble DNC which explains high efficiency of the complex. Nicarbazin breaks to DNC and HDP in the minimal lower digestive tract segment which may be absorbed independently.

       The concurrent effect of monensin and nicarbazin prevents development of eimeria resistance to the product.

       The product is very little absorbed in the digestive tract of poultry and has an effect upon eimeria in the mucous membrane of digestive tract, egested of the organism with fecal matter. It refers to the class of low toxic substances (4th safety class) in terms of degree of organism exposure. 

It is compatible with vitamins and feed additives used in poultry farming.

Indications

Preventive treatment of eimerioses in chicken (broilers, rearing stock to 16 weeks old) and turkey (to 16 weeks old) caused by:

• chicken: Eimeria tenella, E. acervulina, E. brunetti, E. maxima, E. necatrix и E. mivati;

• turkeys: E. gallopavonis, E. maleagrimitis, E. adenoides.

Dosage

       EYmerisan 88 is mixed with feed and given to poultry in a dose:

       0,5-0,625 kg of the product (equivalent to 40-50g of monensin/nicarbazin) per 1 ton of feed. The medicinal product is administered in one-day old broilers with feed within the entire period of breeding and is removed off the ration 5 days prior to slaughter; for turkeys and rearing stock of chicken - from one-day old to 16-weeks old.

 In order to get homogenous feed, EIMERISAN 88 is first mixed with a small quantity of feed and then mixed with the rest of feed. The equipment where the medicinal product was mixed with feed is to be thoroughly cleaned prior to preparation of other premixes or feeds.

Contradictions

Not to be used by laying hens!

Not to be used by rearing stock of chicken and turkeys after 16 weeks!

Not to be combined with tiamulin! Tiamultin treatment is allowed in 7 days after the most recent feeding that contains monensin and nicarbazin.

Not to be combined with other coccidiostats!

Not to be used by horses and other perissodactyls!

Precaution

Poultry slaughter for meat is allowed in 5 days after the most recent product application.

Primary Packing

The polyethylene film packages of 50, 100, 500 g, 1 kg and bags of 5, 10, 20 and 25 kg.

Polymer containers of 100, 500 g and 1 kg.

Storage

Dry, dark place at a temperature from 0 to 25 ° С out of reach of children.

Expiry Period

2 years 

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