PerFect TRIO parasite collar for cats

CHARACTERS

A polymeric tape with a buckle of various colors with a characteristic odor of the components. When stored, blushing is possible.

COMPOSITION

1 g of the collar contains:

Active substances:

- fipronil – 50,0 mg;

- ivermectin – 12,0 mg;

- pyriproxifen – 20,0 mg.

Excipients: Dimethyl sulfoxide, isopropanol, PVC tape.

PHARMACOLOGICAL PROPERTIES

ATCvet QP53А, ectoparasiticides, insecticides and repellents.

The collar exerts a pronounced insectoacaricidal effect with respect to both larval and adult stages of fleas, fluff louses, chewing louses, ticks (Ixodidae and Sarcoptoidea), intestinal nematodes, and Dirofilaria larvae in dogs and cats.

PerFect TRIO Collar is a combination medicinal product containing fipronil, ivermectin, and pyriproxifen.

Fipronil, (RS)-5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-(trifluoromethylsulfinyl)-1H-pyrazole-3-carbonitrile, is a phenylpyryrazole derivative with an insecticidal and acaricidal effect..

Fipronil disturbs the process of the passage of chloride ions in the GABA – dependent receptors of ectoparasites; neural transmission, and nervous system activity, causing the death of the arthropodas. It exerts no effect on the central nervous system in the mammals. Following application to the skin, fipronil is accumulated in the epidermis, hair follicles, and adipose glands of the animal and has a long-lasting insectoacaricidal contact effect.

Ivermectin belongs to the chemical group of macrocyclic lactones. The pharmacological action of ivermectin consists in that it acts as an agonist of the GABA (gamma-aminobutyric acid) neurotransmitter in nerve cells and also binds to glutamate-gated chloride channels in nerve and muscle cells of invertebrates. In both cases it blocks the transmission of neuronal signals of the ectoparasites and nematodes, which are either paralyzed and expelled out of the body, or they starve.

Pyriproxifen is a juvenile hormone analog, which, by disturbing the chitin synthesis and molting processes in larvae, hampers the growth of competent pupae and causes the death of insects at the preimaginal stages of development this resulting in the termination of population replenishment at the egg and larva stages, prevents the sexually mature insects from being occurred on animals and at the places of keeping them. In adult insects, the medicinal product does not cause the death but rather causes adult insect sterilization thereby killing in fact the insect population.

The active substances of the collar are released gradually from the tape surface to the animal’s coat ensuring a long-lasting residual activity.

The collar is toxic to fish and bees.

INDICATIONS FOR USE

Prevention of and treatment for ectoparasite and endoparasite invasion in cats:

- Fleas (Ctenocephalides spp., Pulex irritans);

- Fluff louses (Linognathus setosus);

- Chewing louses (Trichodectes canis, Felicola subrostratus);

- Mosquitoes of three genera: Aedes, Culex, and Anopheles;

- Ticks in the family ixodidae, the hard ticks (Ixodes spp., Dermacentor spp., Haemaphysalis spp., Rhipicephalus spp., Boophilus calcaratus) at the imaginal, nymphal, and larval stages;

- Acariformes (Otodectes cynotis, Notoedres cati, Sarcoptes canis, and Cheyletiella spp.);

- Trombidiformes (Demodex canis, D. gatoi, D. felis);

- Digestive tract nematodes (Toxocara spp., Toxascaris spp., Trichuris vulpis, Uncinaria stenocephala, and Ancylostoma spp.);

- Larvae (stages L3 and L4 microfilaria) of Dirofilaria immitis and Dirofilaria repens.

ROUTE OF ADMINISTRATION AND DOSAGE

Take the collar out of the package and keep at a dry, well-ventilated place out of reach of children and animals for 30 minutes, then put the collar on the neck of the animal, fix it so that a gap of between 1 cm and 2 cm is left between the neck and the collar, and then secure the collar with the buckle.

The collar should be loose on the neck and should not retard the growth of the animal. When secured, the properly fitted collar moves freely around the neck.

The permanent use of the collar ensures the protection of the animal against ticks for up to 3 months, against insects for up to 4 months, and against helminthes for up to 2 months.

The action of the collar against ticks commences 48 hours after the beginning of use; therefore, the collar is recommended to be put on 2 to 3 days prior to an expected contact to parasites. If impossible to do so, examine the animal carefully before putting on the collar to remove any ticks. If the animal is heavily infested with insects, prior to use, wash the animal with an insecticidal shampoo and replace the litters or treat them with an insecticidal agent in accordance with its instructions for use.

CONTRAINDICATIONS

Hypersensitivity to the components of the medicinal product!

Do not use in kittens of up to 2 months of age!

Do not use in debilitated, sick, and starved animals!

Do not use to treat other animal species.

Do not use in animals during pregnancy and lactation.

PRECAUTIONS

In the event of an individual hypersensitivity of the animal to the collar components and if any skin irritation signs appear, terminate the use of the collar.

When handling the medicinal product, the general rules of personal hygiene and occupational safety and health when handling veterinary medicinal products should be complied with.

Take off the collar when washing animals. The action of the collar against parasites will be renewed within 48 hours after the collar is put on repeatedly. During this period of time, an additional protection in the form of the PerFect Insectoacaricidal Spray is recommended to be used.

In the event of manifestation of allergic reactions in an animal sensitive to the components of the medicinal product, prescribe antihistaminic agents and symptomatic treatment.

Do allow animals wearing the collars to contact small children.

HOW SUPPLIED

A 35±5-cm long PVC tape packaged in a PE or PVC film pack. Secondary package: individual can.

STORAGE

Store in a closed original package at a dry place separately from feed and food at between 5 °С and 25 °С. Keep out of reach of children.

SHELF LIFE

2 years.