| Ingredients: | ofloxacin |
| Application: | local application |
| Type of formulation: | antibiotic |
DESCRIPTION
A clear solution, ranging from colorless to light yellow or light yellow-green, with a characteristic odor of the components.
COMPOSITION
1 ml of the product contains the active substance:
- оfloxacin – 3.0 mg.
Excipients: benzalkonium chloride, sodium thiosulfate, Trilon B, sodium chloride, hydroxypropylmethylcellulose, hydrochloric acid, sodium hydroxide, water for injections.
PHARMACOLOGICAL PROPERTIES
ATC vet classification code QJ01 – Antibacterial veterinary drugs for systemic use. QJ01MA01 – Ofloxacin.
Ofloxacin is an antibiotic from the fluoroquinolone group, active against Gram-negative microorganisms, such as Escherichia coli, Salmonella spp., Proteus spp., Shigella spp., Klebsiella spp., Enterobacter spp., Campylobacter spp., Yersinia spp., Pseudomonas aeruginosa, Vibrio spp., Aeromonas spp., Haemophilus spp., Serratia spp., Chlamydia spp.. It is also effective against some Gram-positive microorganisms, including Staphylococcus spp. (including penicillinase-producing and methicillin-resistant strains), Streptococcus spp.. Enterococcus faecalis, Pseudomonas spp., and Streptococcus pneumoniae are moderately sensitive to ofloxacin. The product is also effective against Brucella spp., Mycoplasma spp., and Mycobacterium spp..
The mechanism of action of ofloxacin involves the inhibition of bacterial DNA gyrase (topoisomerase II), which leads to the cessation of DNA supercoiling and synthesis.
A significant advantage of this product compared to other locally acting antibiotics is its high permeability into the cornea and the anterior chamber of the eye. Ofloxacin has the best ability to penetrate the cornea and anterior chamber among all fluoroquinolones, with its effective concentration in the tear film remaining even 4 hours (240 minutes) after application. The MIC90 is over 2 µg/ml. Systemic absorption after local administration into the conjunctival sac is minimal and clinically insignificant.
When applied in the ear with an intact tympanic membrane, ofloxacin is minimally absorbed into the middle ear. However, absorption increases with perforations of the tympanic membrane. After ofloxacin administration in adult animals with tympanic membrane perforation, the maximum concentration in serum reaches 10 ng/ml.
When used locally, the therapeutic concentration of ofloxacin is achieved in the tissues of the eye within 30-60 minutes.
After 10 days of treatment at therapeutic doses, the concentration of ofloxacin in the blood serum is 1000 times lower than the standard concentration after oral administration.
INDICATIONS
Treatment of dogs, cats, and small exotic pets (such as decorative rabbits, hamsters, rats, mice, guinea pigs, parrots, and canaries) for acute and chronic eye and ear inflammations caused by bacterial, chemical, or traumatic factors, including: conjunctivitis, blepharitis, keratoconjunctivitis, iritis, iridocyclitis, dacryocystitis, keratitis, corneal erosions, chlamydial eye infections, eye conditions following trauma, foreign body exposure, or aggressive compounds, as well as pre- and post-operative care, and treatment of external and middle ear infections, otorrhea, including those caused by interventions.
DOSAGE
For eye treatment: Instill 1-2 drops into the conjunctival sac every 2–4 hours for the first 2 days, then reduce to 4 times a day. For chlamydial infections, instill 5 times a day.
For ear treatment: Instill 1-4 drops (depending on the animal's body weight) into the ear canal 2-4 times a day until the signs of inflammation disappear.
If there are significant purulent or mucopurulent discharges, perform preliminary hygienic treatment of the eyes or ears before instilling the medication.
Treatment should continue until the symptoms disappear completely, plus an additional 2-3 days.
Do not touch the tip of the dropper to any surface to avoid contamination of the bottle contents.
CONTRAINDICATIONS
Hypersensitivity to the components of the product (including in history).
Do not use simultaneously with tetracyclines, macrolides, lincosamides, or chloramphenicol.
During treatment with ofloxacin, avoid excessive sun exposure or ultraviolet radiation.
Not for use in viral or fungal eye and ear infections.
Not for use in horses.
Do not use simultaneously with theophylline or products containing magnesium, aluminum, or calcium cations, as they interfere with ofloxacin absorption.
Not for use in the presence of resistant strains of pathogens.
PRECAUTIONS
Use according to the instructions.
When applied to the eyes, temporary local discomfort, irritation, itching, and tearing may occur, which typically resolve quickly. Rarely, allergic reactions may occur. Use with caution in animals under 7 days of age and pregnant animals.
FORM OF RELEASE
Polymer or glass bottles with dropper caps, 10 ml, packed in cardboard boxes.
STORAGE
Store in a dry, dark place, inaccessible to children and animals, separate from food and feed, at a temperature between 5 and 25 °C.
SHELF LIFE
3 years.
Once opened, the product should be used within 30 days.
For use in veterinary medicine only!