Bromodox

Bromodox
Bromodox
Ingredients: Bromhexine hydrochloride, Doxycycline hyclate
Application: injecting
Type of formulation: Antibiotic

DESCRIPTION

Liquid from yellow-brown to dark-brown color with a specific odor of its components

INGREDIENTS

Each 1 ml contains active ingredients:
Doxycycline hyclate - 200 mg,
Bromhexine hydrochloride - 5.0 mg.

PHARMACOLOGICAL PROPERTIES

ATC vet code classification QJ01 – antibacterial veterinary drugs for systemic use.

Bromodox – combination product that consist doxycycline and Bromhexine.

Doxycycline – bacteriostatic antibiotic that belongs to the group of tetracyclines. Effects on the ribosome of bacteria, preventing protein synthesis. The drug has a broad spectrum of antimicrobial activity against Gram-positive and Gram-negative bacteria (Staphylococcus spp., Diplococcus pneumoniae, Streptococcus spp., Haemophilus influenza, E. coli, Pneumococci, Bacillus antracis, Clostridium tetani, Clostridium perfringes, Listeria monocytogens, Actinomyces spp., Entirobacter spp ., Klebsiella spp., Salmonella spp., Shigella spp., Yersinia spp.), and mycoplasmas (Mycoplasma spp.), rickettsiae (Rickettsia spp.) and chlamydia (Chlamydia spp.).

Bromhexine is mucolytic (sekretolitychnyy) and expectorant effects. Mucolytic effect is associated with depolymerization and watering mukoproteyinovyh mukopolisaharydnyh and fiber, which improves separation of sputum, thus making it easier to breath. One of the important features of the action of bromhexine is its ability to stimulate the formation of surfactant – a mixture of surfactant lipid-protein-mukopolisaharydnoyi nature, which is synthesized in the cells of the alveoli. Biosynthesis of surfactant is disturbed in different diseases of the respiratory system, caused by Mycoplasma gallisepticum, Mycoplasma synoviae, Ornithobacterium rhinotracheale. This leads to disruption of the stability of the alveolar cells, weakening their reactions to adverse effects.

When combined with the use of doxycycline Bromhexine increases the concentration of antibiotics in upper respiratory tract secretions and sputum, accelerated its absorption, and thus achieving high levels of doxycycline in the blood for a long time and it’s accelerates the healing process. Doxycycline is practically not metabolized and excreted mainly in the faeces form inactive complexes and to a lesser extent in the urine.

INDICATIONS

Treatment of cattle, sheep, goats and pigs with respiratory diseases (pneumonia, pneumonia, enzootic pneumonia of swine, atrophic rhinitis, etc.), digestive tract (colibacillosis, salmonellosis), and patients with conjunctival-keratitis, ungulates rot, staphylococcus, erysipelas, chlamydial infection, wound infection, arthritis and other diseases caused by microorganisms sensitive to doxycycline.

DOSAGE

Intramuscular doses at once:

cattle, sheep, goats – 1.0 ml per 10 kg body weight;

pigs – 0.5-1.0 ml per 10 kg body weight.

If necessary, re-injection to animals is possible only within 48 hours after the first injection.
Due to the possible local swelling and pain reaction when administered drug in a volume exceeding 2.5 ml for pigs and lambs, adult pigs, sheep and goats – 5 ml for cattle – 10 ml recommended drug administered in several places.

CONTRAINDICATIONS

Hypersensitivity to the components of the preparation.
Do not administer to animals with severe renal impairment and liver.
Do not use concurrently with antibiotics penicillin, cephalosporins, as well as calcium-drugs that may reduce the efficacy of the drug.

WARNING

Test the drug preliminarily in a small number of animals (7 to 8 heads). If no complication during 2 to 3 days, use the drag for the entire livestock population.
The use of the medicine to pregnant and lactating animals is permitted only when the pathogen sensitivity to the drug is specified and possible efficacy of prevailing economic losses.
Animals may only be slaughtered for meat not earlier than 21 days after the last treatment.

HOW SUPPLIED

Neutral glass vials of 10-mL, 20-mL, 50-mL,100-mL and 200 mL, closed by a rubber stopper and sealed with an aluminum cover. Secondary package: carton box.

STORAGE

Dry, dark, place inaccessible to children at temperature from 5°C to 25°C.
Shelf life – 2 years.

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