TURYL 5% (suspension for oral use)
| Ingredients: | Toltrazuril |
| Application: | oral |
| Type of formulation: | Coccidiostatic |
Description
Suspension from white to yellowish color. Upon storage, the suspension is stratified.
Composition
1 ml of the preparation contains active substance:
- toltrazuril - 50 mg.
Auxiliary substances: sodium propionate, sodium benzoate, docusate sodium, хanthan gum, propylene glycol, citric acid, simethicone emulsion, bentonite, purified water.
Pharmacological properties
ATCvet QP51, antiprotozal veterinary preparations (QP51AJ01, toltrazuril).
Active substance of the preparation toltrazuril (symmetrical triazinetrione) – effective eimeriostat.
Toltrazuril disturbs intracellular stages of eimeria development, affecting on schizonts, micro- and macrogametes. Disturbs the process of nuclear fission of eimeria and decreases activity of mitochondria responsible for respiratory metabolism.
After oral administration of the preparation, toltrazuril is slowly absorbed in alimentary tract of animals. in organism of animals toltrazuril is partially metabolized with forming of sulfoxide-and sulphon derivatives. Further – almost completely excreted with feces in unchanged form or in the form of toltrazurilsulphon or toltrazurilsulfoxide.
The preparation has no mutagenic, carcinogenic and teratogenic action.
Application
Prophylaxis and treatment of store pigs and cattle at eimeriosis caused by eimeria sensitive to toltrazuril:
- in piglets: Isospora suis, Eimeria arloingi, E. scabra, E. guevarai;
- in calves: Eimeria bovis, E. zuernii, E. alabamensis.
Dosing
The preparation is applied to piglets and store cattle under 9 months of age, orally individually once via special dosing device at a doses:
- to piglets – on 3-5 day of life at a dose 0,4 ml of the preparation for 1 kg of body mass (equal to 20 mg of toltrazuril/1 kg of body mass), but at least 0,5 ml and not more than 2 ml for an animal;
- to calves - from two weeks of age at a dose 3 ml of the preparation to 10 kg of body mass (equal to 15 mg of toltrazuril/1 kg of body mass).
To obtain maximum prophylactic effect and reducing of oocysts number which are released into the environment in unfavorable on eimeriosis farms, the preparation should be administrated to animals before clinical signs of disease arising – during incubation period.
Contra-indications
Increased sensation to toltrazuril!
To animals during pregnancy and lactation, the preparation is not applied!
To ruminant animal with developed ruminal digestion, the preparation is not applied!
Warning
Slaughter of pigs for meat is permitted in 77 days, cattle in 63 days after last administration of the preparation. Obtained before specified period meat is disposed or fed to non productive animals, depending on conclusion of veterinary medicine doctor.
When dealing with the preparation adhere to the general rules of hygiene and safety adopted when working with veterinary preparations.
During working with the preparation smoking, drinking and eating is not allowed.
After the work, you should wash your hands with soap.
When accidental contact with skin or ocular mucoses rinse them with plenty of running water.
People with hypersensitivity to toltrazuril should avoid contacting with the preparation.
In case of allergic reactions arising or of accidental penetration into human organism, consult a doctor immediately (should have package leaflet for the preparation or label).
Form of presentation
Polymeric or glass ampoule (of neutral glass marks NS-1, NS-2, USP-1) of 0,5, 1,0 ml.
Secondary package – cardboard box.
Polymeric or glass vials (of neutral glass marks NS-1, NS-2, USP-1) of 10, 20, 50, 100. Secondary package – cardboard box.
Polymeric or glass vials (of neutral glass marks NS-1, NS-2, USP-1) of 250 ml.
Storage
Dry, dark, out of the reach of children place at a temperature from 5°C to 25°C.
After first preparation withdrawal from the vial, it must be used within 3 months, under condition of storing in a dark place at a temperature from 5 to 25 0С.
Shelf life
3 years.