Ceftiofur-VS

Ceftiofur-VS
Ceftiofur-VS
Ingredients: Ceftiofur hydrochloride
Application: Injection
Type of formulation: Antibiotic
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DESCRIPTION

Oily suspension from white to yellowish color.

COMPOSITION

Each 1 ml contains the active ingredient:
Ceftiofur hydrochloride – 50 mg.

PHARMACOLOGICAL PROPERTIES

ATC vet classification code QJ01 – antibacterial veterinary drugs for systemic use.

Ceftiofur is a semi-synthetic antibiotic from the cephalosporin of third generation. It has a broad spectrum of activity against gram-positive and gram-negative bacteria (Pasteurella haemolytica (Mannheimia spp.), Escherichia coli, Pasteurella multocida, Haemophilus somnus, Fusobacterium necrophorum and Bacteroides melaninogenicus (Porphyromonas asaccharolytica), Arcanobacterium pyogenes, Fusobacterium necrophorum, Arcanobacterium pyogenes, Pasteurella multocida, Actinobacillus pleuropneumoniae and  Streptococcus suis). Ceftiofur blocks the synthesis of bacteria cell walls by inhibiting the synthesis of peptidoglycan.

After the injection ceftiofur quickly undergoes metabolism and produces desfuroylceftiofur, an active metabolite. Through binding to plasma proteins, the active metabolite of ceftiofur is concentrated at the site of inflammation.

The maximum blood plasma concentration occurs after 1-2 hours from the administration.

Ceftiofur is excreted primarily in the urine and partly with faeces.

APPLICATION

Cattle: Treatment of animals suffering from acute postpartum endometritis, necrobacteriosis and respiratory diseases, caused by microorganisms (Escherichia coli, Mannheimia haemolytica, Pasteurella multocida, Haemophillus somnus) which are sensitive to Ceftiofur.

Pigs: treatment of animals against respiratory diseases that caused by microorganisms (Pasteurella haemolytica, Pasteurella multocida, Actinobacillus pleuropneumoniae, Streptococcus suis, Salmonella cholerasuis) that sensitive to Ceftiofur.

DOSAGE

Cattle: the treatment of respiratory diseases and acute necrobacteriosis – intramuscularly at a dose of 1 ml per 50 kg of body weight (1 mg of ceftiofur per 1 kg body weight) once a day for 3-5 days; for the treatment of acute postpartum metritis (10 days after calving) – subdermally, 1 ml per 50 kg of body weight (1 mg of ceftiofur per 1 kg body weight) once a day for 5 days.

Pigs: intramuscularly, 1 ml per 16 kg of body weight (3 mg of ceftiofur per 1 kg body weight) once a day for 3 days.

Acute postpartum metritis may require additional supportive therapy.

Before use, the vial should be thoroughly shaken.
The maximum injected amount of the drug at one injection site should not exceed 10 ml.

CONTRAINDICATION

Do not use in animals with hypersensitivity to beta-lactam antibiotics.
Do not use simultaneously with tetracyclines, chloramphenicol, macrolides and lincosamides.
Do not inject intravenously.
Do not use in animals with kidney disease.

WITHDRAWAL PERIOD

Animals may only be slaughtered for human consumption after: 8 days (for cattle) 5 days (for pigs) from the last treatment.
The milk for human consumption can be used without any restrictions.

PRECAUTIONS

The administration of the drug should be performed after conducting a laboratory test on the sensitivity of the bacteria.
Do not use for mass treatment of animals.
Do not use for the prevention of metritis in case of retained placenta.
During pregnancy, the feasibility of using the medication should prevail the risks of its use. The decision to use the medication should be taken by a veterinarian.
Avoid accidental injection to human. If such thing happened – seek medical advice immediately, show the leaflet or label of the medication. It is not recommended to allow people with hypersensitivity to beta-lactam antibiotics to work with this medication.
If the medication gets with contact on skin, wash it with soap and water and rinse well. In case if gets in the eyes - immediately rinse with clean water.

HOW SUPPLIED

Neutral glass vials of 10-mL, 20-mL, 50-mL; 100-mL; and 200-mL, closed by a rubber stopper and sealed with an aluminum cover. Secondary package: cartons.

STORAGE

In a dark, dry place, at 10ºС – 25ºС.
Keep out of reach of children.
Shelf life: 2 years.
The shelf life once opened - 14 days and stored at temperature between 0 and 8 ºС.

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