PREGNERON-VS (solution for injection)

1 ml of the medicinal product contains the active agent:

- medroxyprogesterone acetate - 25 mg.

Excipients: benzyl alcohol, cottonseed oil.

Liquid from colorless to yellow color.

ATC VET С03А, HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE.

The active agent of the preparation is medroxyprogesterone acetate - a synthetic progestin, an analog of progestins produced by the yellow body. The action involves transformstion of the proliferative endometrium into a secretory one, strengthening of hypertrophy of myometrium and suppressing of uterine contractions. Depending on the dose it inhibits the secretion of pituitary gonadotropins, has anti-insulin action. In animals the medroxyprogesterone acetate has a significant adrenocortical effect and can suppress the release of ACTH and cortisol. Medroxyprogesterone also has an anti-estrogenic effect and can reduce testosterone levels in the blood plasma of males.

For prolonged prevention or interruption of estrus in cats and female dogs, as well as prevention of unwanted pregnancies; treatment of pseudopregnancy and pseudolactation of female dogs; treatment of nymphomania in cats.

The drug is administered as a single dose subcutaneously in the withers area or intramuscularly in the thigh area in the following doses:

- to treat pseudopregnancy and pseudolactation: 1.0 ml to female dogs with the body weigh of up to 10 kg,

2.0 ml to female dogs with the body weight from10 to 20 kg, 6.0 ml to female dogs wih the body weight of more than 40 kg.

- to prevent the estrus - 5-10 days before its appearance, for its interruption - within 1-2 days after the appearance of the first signs thereof (behavior change, appearance of mucous discharge with an admixture of blood, attractiveness for the opposite sex):

- to female dogs with the body weight of 2-5 kg - 2.0-3.0 ml of the preparation; with the body weight of 5-10 kg - 3.0-4.0 ml; 10-20 kg - 4.0-6.0 ml; 20- 30 kg - 6,0-8,0 ml; 30-40 kg - 8.0-10.0 ml; with the body weight of more than 40 kg - 10.0-12.0 ml;

- to cats with the body weight of up to 3 kg - 1.0 of the preparation, more than 3 kg - 2.0-4.0 ml.

to treat nymphomania in cats - 1.0-2.0 ml of the preparation.

For a one-time prevention of estrus the preparation is administered as a single dose to female dogs not later than a month before the expected estrus and to cats - immediately after the next estrus.

For a long-term prevention of estrus, the preparation is administered 5-10 days before the beginning of estrus, repeated to female dogs after 5-6 months, to cats - after 4-6 months. In case the female dogs the preparation has been administered to show signs of sexual arousal, it is necessary to make an extraordinary injection of the preparation.

For Siamese cats dosing is determined individually by a veterinary doctor.

Before use, the contents of the vial should be shaken thoroughly until a uniform suspension is obtained.

The preparation can not be used during pregnancy, with pseudopregnancy and pseudolactation, diseases of genitourinary and endocrine systems, disorders of sexual cycle regularity, breast tumors in immature animals (prior to the first estrus).

It is not recommended to administer the preparation, if after the appearance of estrus more than 3 days has passed.

The preparation should not be administered to animals during pregnancy and lactation.

Hypersensitivity to the preparation.

The preparation is used only for female dogs and cats (bitches and female cats).

Do not administer to animals until the first estrus.

Do not inject the preparation in the postoperative period.

It is not recommended for female dogs of greyhounds breeds.

In some cases, inhibition of estrus can be permanent.

Bitches and female cats can still have the ability to fertilize within 10 days after administration of the preparation.

After preparation withdrawal it is recommended to mate animals after the second estrus.

Vials made of neutral glass of grades НС-1, НС-2, УСП-1, sealed with rubber stoppers for aluminum spinning for 1.2, 5, 10, 20, 50 and 100 ml. Secondary package - cardboard box. Storage

Dry dark place out of the reach of children at temperature from 5 °C to 25 °C.

After the first picking out from the vial, the preparation must be used within 10 days under storage conditions in a dark place at a temperature of 8 °C.

For use in veterinary medicine!