TRIMERATYNVET ® (water-soluble powder for oral use)

TRIMERATYNVET ® (water-soluble powder for oral use)
TRIMERATYNVET ® (water-soluble powder for oral use)
Ingredients: Sulfadimidine, Trimethoprim 
Application: Oral
Type of formulation: Antibacterial
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DESCRIPTION

Powder from white to grayish color, with specific odor of the components.

COMPOSITION

Each 1 g contains the active ingredients:
- sulfadimidine – 100.0 mg
- trimethoprim – 20.0 mg

PHARMACOLOGICAL PROPERTIES

ATC vet classification code QJ01 - antibacterial veterinary medicines for systemic use. QJ01EW03 - the combination of sulfonamides and trimethoprim.

Trimeratinvet is a combination preparation consisting of sulfadimidine and trimethoprim. The action is caused by the action of the abovementioned components, which together reveal synergic effect, and as a result the activity of the preparation is significantly higher than the activity of individually taken components.

Sulfadimidine and trimethoprim in combination acts bactericidally against most gram-positive and gram-negative microorganisms, including: Staphylococcus spp., Steptococcus spp., Salmonella spp., E. coli, Pasteurella spp., Serpulina hyodysenteriae, Corynebacterium spp., Erysipelothrix rhusiopathiae.

The mechanism of action is consistent inhibition of enzymes involved in the synthesis of folic acid, thereby inhibiting the synthesis of thymidine bacterial cell. Sulfadimidine blocks the conversion of para-aminobenzoic acid into dihydrofolic and trimethoprim blocks the conversion of dihydrofolic acid into tetrahydrofolic by inhibition of dihydrofolate reductase.

INDICATIONS

Treatment of cattle, sheep, goats, dogs, cats and poultry (broilers and replacements) suffering from diseases of the alimentary canal, respiratory and genitourinary systems, coccidiosis and also the complications of viral diseases, postsurgical and posttraumatic infections caused by pathogens susceptible to trimethoprim and sulfadimidine.

DOSAGE

Orally, dissolved in drinking water or milk substitutes according to the following doses:

- cattle – 1 g.  per 10 – 20 kg of body weight for 3-5 days;

- sheep, goats – 1 g. per 5 – 10 kg of body weight for 3-5 days;

- dogs, cats – 1 g. per 5 – 10 kg of body weight for 3-5 days;

- poultry – 2 – 2.5 g. per 10 kg of body weight or 1 kg of the powder per 1000 liters of the drinking water on a daily basis for 4-7 days.

- in severe cases in poultry, the doses can be increased – 1.5 – 2.0 kg of the powder per 1000 liters of drinking water (4.0 g. per 10 kg body weight) daily for 4-7 days.
The preparation is used with intervals of 24 hours.
The solution is prepared in a ratio of not less than 10 liters of water for 1 kg of the powder, it is necessary to pour 10 liters of drinking water into a capacity and continuously adding small portions of the powder while stirring. Stir until complete powder dissolution. For a more rapid dissolution of the powder – use warm drinking water. Thus prepared concentrate (powder:drinking water – 1:10) should be immediately added to the required amount of drinking water in accordance with the daily giving amount water for different age categories of birds. Prepare a fresh solution on a daily basis.

CONTRAINDICATIONS

Hypersensitivity to sulfadimidine and trimethoprim.
Do not use in animals with violations of liver and kidney functions or with blood dyscrasia.
Do not administer to laying hens producing eggs for human consumption.

PRECAUTIONS

Animals may only be slaughtered for meat 7 days after the last treatment and for milk – 3 days.
Poultry may only be slaughtered for meat 2 days after the last treatment.

HOW SUPPLIED

Packets made of polyethylene pellicle or other polymer pellicle of 3, 50, 100, 500 and 1000 g.

Polymeric containers of 100, 500g. and 1kg.

STORAGE

In the manufacturing container in a dark, dry place, at 5ºС – 25ºС.
Keep out of reach of children.

Shelf life

3 years.

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