Activil-3

Activil-3
Activil-3
Ingredients: Clostridium butyricum 1 * 109 CFU / kgBacillus licheniformis 1 * 1012 cfu / kgBacillus subtilis 1 * 1012 cfu / kg
Application: Orally
Type of formulation: Probiotic

Composition 

1 kg of probiotic feed supplement contains:

Clostridium butyricum 1*109 CFU/kg

Bacillus licheniformis 1*1012 CFU/kg

Bacillus subtilis 1*1012 CFU/kg

Total bacteria count:

Bacillus 2×1012 CFU/kg

Clostridium 1×109 CFU/kg

Excipients: calcium carbonate or dextrin.

Pharmaceutical form

Powder.

Pharmacological properties 

ACTIVIL-3 is a probiotic of the 4th generation. This is a multicomponent biologically active feed supplement containing living bacteria Bacillus licheniformis, Bacillus subtilis, Clostridium butyricum. 

Bacillus subtilis is a spore-forming bacterium suppressing Gram-positive and Gram-negative bacteria by means of their competitive displacement, not causing resistance. 

Bacillus licheniformis is a spore-forming bacterium synthesizing vitamins in the digestive tract, in particular vitamin K, riboflavin, folic acid. Enables maintenance of acid-base balance in the large intestine and nutrients intake. Stimulates growth of probiotic microflora and inhibits growth of pathogenic microorganisms, such as Shigella dysenteriae, restores the intestinal microflora. 

Clostridium butyricum is a spore-forming bacterium synthesizing a large number of short-chain fatty acids, especially the N-oleic acid, which in turn has antimicrobial effect on Gram-negative bacteria, in particular on Escherichia coli, Salmonella sp., Clostridium perfringens. 

The symbiosis of all bacteria listed above allows not only improvement of the intestine microflora, but also significant reduction of the risk of bacterial diseases due to natural displacement of potentially pathogenic bacteria (Escherichia coli, Salmonella sp., Clostridium perfringens) stimulating growth of lactic acid bacteria.

ACTIVIL-3 enables slowing down transit of food masses through the digestive tract, thereby creating conditions for full nutrients intake. Moreover, the excipients prolong digestion and enable increase in the feed conversion. 

Clinical Features

Animals species

Animals and poultry.

Indications for use

The supplement is used as an auxiliary agent to prevent and treat gastrointestinal infections of bacterial and viral etiology, normalize the intestinal microflora in dysbacterioses of various origins, stimulate growth, increase in safety and productivity of the livestock, lengthen the period of egg-laying, decreases the feed-egg ratio.

ACTIVIL-3 reduces feed consumption per production unit, removes stress of various nature, contributes to increase in natural organism resistance and immunity stress level during and after vaccinations. ACTIVIL-3 reduces the level of harmful gases (ammonia, hydrogen sulphide) in livestock houses.  Improves the biological quality of the bedding.

Contraindications

Do not use simultaneously with disinfectants.

Side effects

Not detected

Special precautions for use

Not detected

Application during pregnancy, lactation, egg-laying

Not detected

Interaction with other medications and other interaction types

Probiotic bacteria Bacillus subtilis and Bacillus licheniformis, which are components of the feed supplement have low sensitivity to such antibiotics as colistin sulfate, gentamicin, amoxicillin, neomycin, streptomycin.

When combined with antibiotics of the Gram-positive spectrum, partial decrease in the efficiency of the medication may be observed. 

It is possible to combine with anticoccidial agents.

Doses and methods of administration to animals of different age

Dosage

Animal species

Dosage (g/t)

Animal species

Dosage

(g/t)

Animal species

Dosage (g/t)

Dosage for mixing

with feed

Suckling

piglets

200 – 400

Broilers

100 – 200

Aquacultures

100 – 300

Feeder pigs

150 – 250

Laying hens

100 – 200

Ruminants

100 – 300

Pigs

50 – 150

Boars and breeding sows

100 – 200

Dosage for mixing

with water

Suckling

piglets/feeder pigs

100-250

Broilers/

laying hens

50-100

 

 

Pigs

50-150

Ruminants

100-200

Overdose (symptoms, emergency measures, antidotes)

Overdose was not detected in case of following the recommendations.

Special precautions for each animal species

None.

Clearance period 

Does not apply.

Special precautions for operating personnel

Personnel working with the product shall comply with the general rules of hygiene and safety when working with corresponding products. 

Pharmaceutical features

Forms of incompatibility
None.

Shelf life

18 months from the date of production.

Special storage conditions

Dry dark place out of the reach of children, at a temperature of 5 to 25 °C.

Nature and composition of the primary packaging container

Packages made of polyethylene (polyvinyl chloride, polyethylene terephthalate) film 50, 100, 500 g and 1 kg each. Polymer containers 500 g, 1 kg each.
Bags of 10, 20 and 25 kg  each.

Special precautions for handling unused medications or their residues

Unused residues of the medication of the medication that has expired are disposed of by incineration in a special oven.

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