COLI-OX 200

COLI-OX 200
COLI-OX 200
Ingredients: Colistin sulfate, Oxytetracycline hydrochloride
Application: Oral
Type of formulation: Antibiotic
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DESCRIPTION

Powder from white tolight-yellow color.

COMPOSITION

Each 1 g contains the activeingredients:
- oxytetracycline hydrochloride – 100.0 mg
- colistin sulfate – 1200000units.

PHARMACOLOGICAL PROPERTIES

Coli-Ox 200 – a combinatedpreparation that contains two antibiotics.

Oxytetracycline – anantibiotic that belongs to the group of tetracyclines.

The mechanism of action isinhibition of protein synthesis by binding to the 30S ribosomal subunit ofsusceptible microorganisms thus preventing combination of ribosomes withaminoaciltransport RNA. Oxytetracycline is also believed to be bound reversiblywith 50S ribosomes and to alter the cytoplasmic membrane permeability ofsensitive microorganisms.

Oxytetracycline has a broadspectrum of action on gram-positive and gram-negative microorganisms:Streptococcus spp., Clostridium spp., Corynebacterium spp., Brucella spp.,Haemophilus spp., E. coli, Pasteurella spp., Klebsiella spp., Erysipelothrixspp., Fusobacterium spp., Salmonella spp., as well as on the protozoon(Protozoa spp.), mycoplasmas (Mycoplasma spp.), rickettsiae  Rickettsiaspp.) and Chlamydia (Chlamydia spp.).

Colistin sulfate is anantibiotic belonging to the group of polymyxins which are synthesized by anaerobic spore-forming bacillus Bacillus polymyxa. It acts bactericidally ongram-negative bacteria (such as E. coli, Salmonella spp., Pseudomonas spp.)through binding with phospholipids of the cytoplasmic membrane increasing itspermeability for both intracellular and extracellular components this resultingin the destruction of cellular barriers. 

INDICATIONS

Treatment of pigs, poultry(broilers and Heifer, turkeys), lambs, calves and kid-goats (from birth to 8weeks) suffering from diseases of the gastrointestinal tract and respiratorysystem, caused by organisms susceptible to oxytetracycline and colistin.

DOSAGE

Orally at doses for:

Lambs, calves, and kid-goats(of up to 8 weeks of age): 0.5 g of the drug per 10 kg b.w. twice daily for 5to 7 days;

Pigs, poultry (broilers andHeifer, turkeys): 100 g of the drug per 100 to 200 L of water or 100 g of thedrug per 50 to 100 kg of feed daily for 5 to 7 days.

To prepare the solution, pourthe required quantity of the drug into a small vessel and, while stirringcontinuously, pour warm water. Add immediately the concentrate (the drug +drinking water 1:40) so prepared to the requisite quantity of drinking water inaccordance with water rates for individual age categories of poultry. Prepare afresh solution of the drug every day.

CONTRAINDICATIONS

Hypersensitivity to oxytetracyclineand colistin.
Do not administer to animalswith their liver or kidneys affected.
Do not combine withantibiotics that have a bactericide action such as penicillin, cephalosporin, andaminoglycoside.
Do not combine with non-steroidalanti-inflammatory drugs (NSAID).
Do not administer to layinghens producing eggs for human consumption.
Do not administer to ruminantswith the well-developed rumen.

PRECAUTIONS

During mixing the drug withfeed, use individual protection equipment (a respirator, gloves).

Test the drug preliminarily ina small number of animals (7 to 8 heads). If no complication during 2 - 3 days,use the drag for the entire livestock population.

Animals may only beslaughtered for meat 10 days after the last treatment.

Poultry may only beslaughtered for meat 7 days after the last treatment.

HOW SUPPLIED

1g, 10g, 50g, 100g, 1kg, and25-kg polyethylene packs or cartons.

STORAGE

Store at a dry place protectedfrom light at between 5ºС and 25ºС. Keep out of reach ofchildren.

Shelf life

2 years

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