DECOCCIL (granules for oral administration)

Description

Light-brown – brown granules with slight specific odor.

Composition

1 of medicinal product contains active ingredients:

- decoquinate - 60 mg.

Pharmacological Properties

ATCvet QP51, antiprotozoal veterinary products (ATCvet QP51AX14, decoquinate)

Decoquinate as a component of the product has a wide spectrum of antiprotozoal effect, effective against Toxoplasma spp, Eimeria tenella, E. acervulina, E. necatrix, E. maxima, E. brunetti, E. mitis, E. praecox, E. bovis, E. zuernii, E. ellipsoidalis, E. cylindrica, Eimeria arloingi, E. ninaekohljakimovae, E. intricata, E. faurei and other types of eimeria.

Decoquinate is the antiprotozoal composition of 4- Hydroxyquinoline, retains eimeria development at the early phases. The mode of action of decoquinate lies in disturbance of electrons transportation in the mitochondrial cytochrome system of eimeria.

Decoquinate has its effect in digestive tract of stock and poultry, is poorly absorbed and egested unchanged with fecal matter. As a result, decoquinate remnants in tissues are insignificant and are promptly excreted.

It is compatible with vitamins and feed additives used in poultry farming and cattle breeding. The product is moderately toxic for homoiotherms.

Indications for Usе

Treatment and preventive treatment of eimerioses in chicken (broilers, rearing stock), horned cattle (calves) and sheep (lambs) caused by eimeria:

- horned cattle (calves): Eimeria bovis, E. zuernii, E. ellipsoidalis, E. cylindrica;

- sheep (lambs): Eimeria arloingi, E. ninaekohljakimovae, E. intricata, E. faurei;

- Broiler chicken, rearing stock: Eimeria acervulina, E. maxima, E. tenella,E. necatrix, E. brunetti.

Preventive treatment of abortions and perinatal losses related with ewes’ toxoplasmosis.

Dosage

Preventive treatment of eimerioses in broilers chicken, rearing stock:

The product dose constitutes 0,333 - 0,667 kg/1 tn of feed equivalent to 20-40 mg of decoquinate/1 kg of feed. The product with feed is given to chicken within the entire feeding period (from the first days of life) removing the product off the ration 3 days prior to slaughter.

Lambs and calves eimeriosis treatment:

The product dose constitutes 1,67 kg of the product /1 tn of feed equivalent to 100 mg of decoquinate/1kg of compound feed (100ppm).

The recommended dose for stock constitutes 1 mg of decoquinate/ kg of body mass per day. If lambs are fed with limited amount of compound feed (for instance, less than 100 g/10 kg of body mass per day) or calves are fed with less feed than the recommended amount of 500 g/50 kg of body mass per day, the product dose shall be correspondingly increased to get the recommended dose (1 mg of decoquinate/ kg of body mass per day). For instance:

Daily consumption of compound feed:

To be used with feed within 28 days. If required, the treatment regimen may be extended.

Preventive treatment of eimerioses with lambs and calves:

The recommended dose of decoquinate constitutes 50 mg/kg of feed (50 ppm) corresponding to 833 g of DECOCCIL product/tn of compound feed. If lambs and calves get limited quantity of feed (for instance, less than 500 g/50 kg of body mass per day), the product dose is to be equally increased to achieve the recommended dose of 0,5 mg of decoquinate/kg of body mass per day.

The product is given to ewes with compound feed at least within 28 days in the period of possible oocysts excretion and risk of lambs’ invasion (i.e., before, during and after lambing), and calves in the period of hazard of eimerioses propagation.

Such a method of application of DECOKCIL product with compound feed ensures effective preventive treatment of oocysts excretion from ewes. In more severe cases, the product dose is to be increased twice.

Preventive treatment of abortion and perinatal losses caused by toxoplasmosis, when using DECOKCIL with compound feed for ewes:

- used by ewes in gestation period (pregnancy). The recommended dose of active ingredient of the product is 2, 0 mg/kg of body mass per day.

- second gestation trimester (the medium pregnancy period): 6,68 kg of DECOKCIL product/g of compound feed to be given in a dose of 250 g/50 kg of body mass per day;

- third gestation trimester (the late pregnancy period): 3,34 kg of DECOKCIL product/g of compound feed to be given in a dose of 500 g/50 kg of body mass per day;

- If ewes get other quantity of feed, the dose of the product for the stock to receive the recommended decoquinate dose (2,0 mg/kg of body mass) is to be accordingly calculated.

The product shall be fed within two last trimesters of gestation (last 14 weeks).

The farms where the cases of abortions caused by toxoplasmosis have been previously registered, the ewes susceptible to toxoplasmosis (the new stock purchased or introduced to flock) are advised to be separated from others from the economic viewpoint and to be given the product with compound feed as the most of older ewes have adaptive immunity to toxoplasmosis.

When mixing the medicinal product with feed, its homogenous distribution is to be ensured (multistage mixing).

Contradictions

Not to be used by does (ewes, cows) during lactation which milk is consumed by people!

Not to be used by laying hens!

Precaution

The run out (quarantine) period: horned cattle, sheep meat – 0 days, broiler chicken meat – 3 days.

The personnel working with the product is to observe the basic rules of safety and hygiene established for operations with veterinary products.

Primary Packing

The polyethylene film packages of 50, 100, 500 g, 1 kg and bags of 5, 10, 20 and 25 kg.

Polymer containers of 100, 500 g and 1 kg.

Storage

Dry, dark place at a temperature of 0 to 25 ° С out of reach of children.

Expiry Period

2 years of manufacture date.

After primary packing has been removed the expiry period is 3 months, the expiry period in the ready feed is 3 months.