A milky white colored emulsion; separates into layers when stored; an insignificant precipitate is tolerable.
ATCvet Code: QA11J, Other Vitamin Products, Combinations.
The effect of the product is due to the properties of vitamin E and sodium selenite. Vitamin Е takes part in the synthesis of proteins, lipids, and carbohydrates; stabilizes spermiogenesis, the metabolism of unsaturated fatty acids; prevents lipid peroxide oxidation from occurring; prevents peroxide and hydroperoxide compounds from being formed. Tocopherol is incorporated into lipoprotein structure of membranes and ensures thereby their structural and functional stability. It stimulates erythropoiesis, the synthesis of heme which is incorporated into hemoglobin and myoglobin, tissue respiratory enzymes – peroxidases and cytochromes, and catalase which hydrolyzes hydrogen peroxide. Selenium is incorporated into glutathione peroxidase, an important enzyme of an antioxidant protection of the body which destroys not only hydrogen peroxide but also peroxidates which are formed as a result of the oxidation of unsaturated fatty acids. Selenium is a component of selenoproteins such as selenocysteine and selenomethionine which plays a crucial role in thyroid gland functioning. Selenium deficiency causes a decrease in thyroid gland hormone synthesis and may be one of the factors of autoimmune thyroiditis development.
SETOL-E is indicated in case of hypovitaminosis E, white-muscle disease and myodystrophy, hepatodystrophy and hepatitis in animals; thyroid gland diseases; in case of stress and diseases such as encephalomalacia, myodystrophy, and exudative diathesis in poultry.
Dosage and Administration
Administer orally via drinking water at a dose level of:
Calves, sheep, and goats – 1 mL per 40 kg of body weight for 5-7 days;
Cattle – 1 mL per 80 kg of body weight for 5-7 days;
Poultry, young pigs – 1 mL per 4000 L of drinking water for 5-7 days; and
Chicks (of up to 21 days of age) – 1 mL per 1000 L to 2000 L of drinking water for 3-5 days.
Prior mixing into drinking water, shake the product thoroughly.
In preparing a stock solution, add the product while stirring to drinking water but not vise versa. Prepare the stock solution at a ratio of 1:10 to 1:20; a white-colored emulsion with a characteristic odor is formed.
An excessive level of selenium in the body and feed (alkali disease).
Hypersensitivity to selenium.
None reported if used at the recommended dose levels.
Overdose (Symptoms, Emergency Procedures, Antidotes)
If overdosed, selenium may cause toxic phenomena.
Antidotes: unithiol, sodium thiosulfate, methionine.
Special Precautions for Use
Test the product preliminarily in a small number of animals (7 to 8 animals). If no complication during 2 to 3 days, use the product for the entire livestock population.
10-mL, 20-mL, 50-mL, 100-mL, and 200-mL glass vials closed by rubber stoppers and sealed with aluminum caps and 1-L and 5-L polymeric vials.