HEPAXIN (injection)

DESCRIPTION

An oily liquid ranging from colorless to light yellow.

COMPOSITION

1 ml of the product contains the active ingredients:

- L-arginine – 40.0 mg

- L-ornithine – 15.0 mg

- L-citrulline – 10.0 mg

Excipients: Betaine hydrochloride, sorbitol, lidocaine hydrochloride, methylparaben, propylparaben, water for injections.

PHARMACOLOGICAL PROPERTIES

ATC-vet classification code QA05 – Veterinary medicines used for liver and biliary tract pathology.

HEPAXIN is a hepatoprotective agent that combines the pharmacological properties of its components with a pronounced stimulating, protective, and choleretic effect on the liver, improving its functions and metabolism, thereby optimizing key physiological processes.

L-arginine stimulates cellular metabolism, aids in the detoxification and elimination of ammonia, regulates blood sugar levels, reduces lactic acidosis caused by muscle exertion, activates nitrogen-containing enzymes, and synthesizes the nitroso group, providing necessary arterial tone.

L-ornithine participates in the urea cycle (formation of urea from ammonia), reduces elevated ammonia levels in the body due to liver diseases, aids in insulin and growth hormone synthesis, and activates protein metabolism.

L-citrulline is an amino acid involved in the urea formation cycle, promoting the excretion of urea from the body.

Betaine is a natural source of methyl groups and a hepatoprotective agent that positively influences metabolism, improves intestinal epithelium condition, enhances energy absorption from the diet, increases stress resistance, has choleretic and lipotropic effects, activates metabolic methylation in the liver, and synthesizes phospholipids for cellular membranes.

Sorbitol is an energy substance that accumulates in the liver as glycogen, partially compensating for negative energy balance, and has a pronounced diuretic effect.

The use of the product increases endurance, improves heart function, reduces subcutaneous fat, increases muscle mass by accelerating metabolic processes in cells, enhances the penetration of vitamins, minerals, and waste products into cells. The product reduces the risk of fatty liver dystrophy, nephrosis, myocardosis, prevents stress (thermal, transport, etc.), improves appetite and feed absorption, enhances digestion and fat absorption, which is especially important during intensive growth periods in animals.

The product is quickly absorbed from the injection site, passes through the histohematological barrier, and is distributed throughout all organs and tissues. It is partially utilized in metabolic processes, with the rest excreted by the kidneys.

The product is considered low in toxicity and does not exhibit embryotoxic, teratogenic, carcinogenic, or sensitizing effects at therapeutic doses.

INDICATIONS

Used alone or as part of combination therapy for acute and chronic liver diseases of various etiologies, to normalize liver function and regenerate liver cells after endo- and exotoxicoses, somatic or infectious diseases, to reduce hepatotoxic effects of drugs, accelerate liver recovery during periods of intensive overload, normalize metabolism, increase overall resistance and productivity, prevent and treat stress periods, and accelerate growth during animal fattening.

DOSAGE AND ADMINISTRATION

The product is administered to animals either deeply intramuscularly or slowly intravenously at the following doses:

Note:

Foals are horses under 1 year old,

Lambs are sheep under 4 months old,

Calves and piglets are animals under 6 months old.

The course of treatment can be extended up to 2 weeks as recommended by a veterinarian.

CONTRAINDICATIONS

Increased individual sensitivity to the components of the product (including history of such sensitivity). In case of hypersensitivity to the components, or if allergic reactions occur, the use of the product should be discontinued, and if necessary, antihistamines and symptomatic therapy should be prescribed.

PRECAUTIONS

Side effects:

In the recommended doses, side effects are generally not observed. If side effects such as itching, nausea, vomiting, or muscle tremors occur, the use of the product should be stopped and desensitizing therapy should be applied.

The product is not recommended to be mixed with other veterinary products.

FORM OF RELEASE

Flacons made of neutral glass (types NS-1, NS-2, USP-1) sealed with rubber stoppers under aluminum crimp caps, with volumes of 10, 20, 50, 100, and 200 ml. Secondary packaging: cardboard box.

STORAGE

Store in the manufacturer's sealed packaging, in a dry, protected from direct sunlight, and out of reach of children and animals. Keep separately from food and feed, at a temperature between 5°C and 25°C.

SHELF LIFE

2 years.

Shelf life after first opening the primary container, under proper storage conditions: no more than 21 days.

For use in veterinary medicine only!