PerFect® TRIO Parasite Drops for Cats

PerFect® TRIO Parasite Drops for Cats
Ingredients: Fipronil, ivermectin, pyriproxifen
Application: External use
Type of formulation: Insectoacaricidal products

CHARACTERS

A yellowish to yellow-brown, oily liquid with a characteristic odor of the components. When stored, an insignificant precipitate is tolerable.

COMPOSITION

1 mL of the product contains:

- Active substances:

Fipronil – 100,0 mg;

Ivermectin – 15,0 mg;

Pyriproxifen – 20,0 mg.

- Excipients:

Dimethyl sulfoxide, benzyl alcohol, glycerol formal.

PHARMACOLOGICAL PROPERTIES

ATCvet QP53А, Ectoparasiticides for topical use, incl. insecticides

The product exerts a pronounced insectoacaricidal effect with respect to both larval and adult stages of fleas, fluff louses, chewing louses, ticks (Ixodidae and Sarcoptoidea), intestinal nematodes, and Dirofilaria larvae in dogs and cats.

PerFect® TRIO drops is a combination medicinal product containing fipronil, ivermectin, and pyriproxifen.

Fipronil, (RS)-5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-(trifluoromethylsulfinyl)-1H-pyrazole-3-carbonitrile, is a phenylpyryrazole derivative with an insecticidal and acaricidal effect.

Fipronil disturbs the process of the passage of chloride ions in the GABA – dependent receptors of ectoparasites; neural transmission, and nervous system activity, causing the death of the arthropodas. It exerts no effect on the central nervous system in the mammals. Following application to the skin, fipronil is accumulated in the epidermis, hair follicles, and adipose glands of the animal and has a long-lasting insectoacaricidal contact effect. Following application of the product, fipronil is distributed across the body surface within 24 hours.

Ivermectin belongs to the chemical group of macrocyclic lactones. The pharmacological action of ivermectin consists in that it acts as an agonist of the GABA (gamma-aminobutyric acid) neurotransmitter in nerve cells and also binds to glutamate-gated chloride channels in nerve and muscle cells of invertebrates. In both cases it blocks the transmission of neuronal signals of the ectoparasites and nematodes, which are either paralyzed and expelled out of the body, or they starve.

Pyriproxifen is a juvenile hormone analog, which, by disturbing the chitin synthesis and molting processes in larvae, hampers the growth of competent pupae and causes the death of insects at the preimaginal stages of development this resulting in the termination of population replenishment at the egg and larva stages, prevents the sexually mature insects from being occurred on animals and at the places of keeping them.

Is applied to the skin at the recommended dose levels, the medicinal product exerts neither topically irritating effect nor resorptive toxic effect; on contact to eyes, causes irritation. The medicinal product is toxic to fish and bees.

INDICATIONS FOR USE

Prevention of and treatment for ectoparasite and endoparasite invasion in cats:

● Fleas (Ctenocephalides spp., Pulex irritans);

● Fluff louses (Linognathus setosus);

● Chewing louses (Trichodectes canis, Felicola subrostratus);

● Mosquitoes of three genera: Aedes, Culex, and Anopheles;

● Ticks in the family ixodidae, the hard ticks (Ixodes spp., Dermacentor spp., Haemaphysalis spp., Rhipicephalus spp., Boophilus calcaratus) at the imaginal, nymphal, and larval stages;

● Acariformes (Otodectes cynotis, Notoedres cati, Sarcoptes canis, and Cheyletiella spp.);

Trombidiformes (Demodex canis, D. gatoi, D. felis);

Digestive tract nematodes (Toxocara spp., Toxascaris spp., Trichuris vulpis, Uncinaria stenocephala, and Ancylostoma spp.);

● Larvae (stages L3 and L4 microfilaria) of Dirofilaria immitis and Dirofilaria repens.

ROUTE OF ADMINISTRATION AND DOSAGE

Prescribe the medicinal product once to adult cats and kittens of 3 months and more of age and 2 kg and more in body weigh.

Apply the medicinal product to a dry intact skin of animals in the area of the back of the head, or, in the event of infestation with Otodectes cynotis, to the pinna skin. In order to apply the medicinal product, cut the pipette tip off and split the hairs apart so that the skin is visible, press the pipette tip to the skin, and squeeze the pipette several times to apply the entire contents to the skin.

Apply the medicinal product at the following dose levels:

Cats of up to 4 kg in body weight: 1 pipette containing 0.6 mL of the medicinal product;

Cats of between 4 kg and 10 kg in body weight: 1 pipette containing 0.8 mL of the medicinal product.

On the infestation with the ixodidae, apply the medicinal product at a dose level of 1 drop directly to the tick and the site of its attachment to the skin. If the tick does not fall off within 20 minutes, take it out carefully with a forceps.

For the therapeutic purpose in sarcoptic mange, demodecosis, and notoedric mange, apply the medicinal product 2 to 4 times at an interval of between 7 and 10 days; for the preventive purpose, apply the medicinal product once a month. Treatment is recommended to carry out combined with etiotropic therapy, nosotropic therapy, and symptomatic therapy.

In order to treat otoacariasis (ear mange), use PerFect® TRIO drops once. In the course of treatment, the acoustic meatus is recommended to be cleaned of exudate and crusts, and in the event of complication with otitis, antimicrobial and anti-inflammatory agents are recommended to be prescribed. Repeat the treatment course, if required.

The protective action of the medicinal product after a single treatment of an animal lasts for up to 21 days against ticks and for up to 1.5 months against insects.

Repeated treatments of animals with the medicinal product during the season of activity of parasites are recommended to be carried out symptomatically, but in no event more often than once a month. For the purpose of preventing a repeated invasion of fleas, replace the litters or treat them with an insecticidal agent in accordance with its instructions for use.

CONTRAINDICATIONS

Hypersensitivity to the components of the medicinal product!

Do not use in kittens of up to 3 months of age and up to 2 kg in body weight!

Do not use in debilitated, sick, and starved animals!

Do not use to treat other animal species, especially rabbits, because of the risk of adverse reactions which may result in the death of animals.

Do not use in pregnant animals and females during lactation.

PRECAUTIONS

When handling the medicinal product, the general rules of personal hygiene and occupational safety and health when handling veterinary medicinal products should be complied with.

In the event of manifestation of allergic reactions in an animal sensitive to the components of the medicinal product, prescribe antihistaminic agents and symptomatic treatment.

Do not allow the animals to lick the medicinal product off; keep them away from open flame and heating devices.

Do not wash the animals 3 days before and after treatment with the medicinal product.

It is of importance to comply with the rules for safe animal fixation.

After the treatment of animals, wash the hands with soap and water.

For 48 hours of treatment, do not pat the animals and do allow the animal to contact small children.

Avoid eye contact.

HOW SUPPLIED

0.6-mL; 0.8-mL; 1.6-mL; 2.5-mL; 4.0-mL polymeric dropping ampoules packaged in a carton in the quantity of 3 or 6 ampoules; 0.6-mL; 0.8-mL; 1.6-mL; 2.5-mL; 4.0-mL polymeric dropping ampoules in an individual cardboard pack.

STORAGE

Store at a dry place protected from light separately from feed and food at between 5 °С and 25 °С. Keep out of reach of children.

SHELF LIFE

18 months.

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