ATC vet code classification QJ01 – antibacterial veterinary drugs for systemic use.
Bromodox – combination product that consist doxycycline and Bromhexine.
Doxycycline – bacteriostatic antibiotic that belongs to the group of tetracyclines. Effects on the ribosome of bacteria, preventing protein synthesis. The drug has a broad spectrum of antimicrobial activity against Gram-positive and Gram-negative bacteria (Staphylococcus spp., Diplococcus pneumoniae, Streptococcus spp., Haemophilus influenza, E. coli, Pneumococci, Bacillus antracis, Clostridium tetani, Clostridium perfringes, Listeria monocytogens, Actinomyces spp., Entirobacter spp ., Klebsiella spp., Salmonella spp., Shigella spp., Yersinia spp.), and mycoplasmas (Mycoplasma spp.), rickettsiae (Rickettsia spp.) and chlamydia (Chlamydia spp.).
Bromhexine is mucolytic (sekretolitychnyy) and expectorant effects. Mucolytic effect is associated with depolymerization and watering mukoproteyinovyh mukopolisaharydnyh and fiber, which improves separation of sputum, thus making it easier to breath. One of the important features of the action of bromhexine is its ability to stimulate the formation of surfactant – a mixture of surfactant lipid-protein-mukopolisaharydnoyi nature, which is synthesized in the cells of the alveoli. Biosynthesis of surfactant is disturbed in different diseases of the respiratory system, caused by Mycoplasma gallisepticum, Mycoplasma synoviae, Ornithobacterium rhinotracheale. This leads to disruption of the stability of the alveolar cells, weakening their reactions to adverse effects.
When combined with the use of doxycycline Bromhexine increases the concentration of antibiotics in upper respiratory tract secretions and sputum, accelerated its absorption, and thus achieving high levels of doxycycline in the blood for a long time and it’s accelerates the healing process. Doxycycline is practically not metabolized and excreted mainly in the faeces form inactive complexes and to a lesser extent in the urine.
Intramuscular doses at once:
cattle, sheep, goats – 1.0 ml per 10 kg body weight;
pigs – 0.5-1.0 ml per 10 kg body weight.