Enrofloxvet 10% (Solution for injection)

Enrofloxvet 10% (Solution for injection)
Enrofloxvet 10% (Solution for injection)
Ingredients: Enrofloxacin base
Application: Injection
Type of formulation: ANTIBIOTIC
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DESCRIPTION

Clear solution, from pale yellow to yellow color.

COMPOSITION

Each 1 ml contains the active ingredient:
enrofloxacin - 100 mg.
Excipients: 1,2 - propylene glycol, water for injections.

PHARMACOLOGICAL PROPERTIES

Enrofloxacin belongs to the fluoroquinolone group of antibiotics. Its mechanism of action is associated with inhibition of subunit A of DNA-gyrase (topoisomerase II) Gram-negative bacteria, which blocks the process superspiralizatsiyi DNA molecule. In gram-positive bacteria, this process affects topoisomerase IV, rather than topoisomerase II. Under these conditions, transcription and recombination process are blocked in bacteria’s DNA.

The preparation has bactericidal action against Gram-positive (Staphylococcus spp., Streptococcus spp., Clostridium spp., Listeria monocytogenes, Corynebacterium spp. Etc.) and Gram-negative bacteria (E. coli, Salmonella spp., Klebsiella spp., Proteus spp., Pasterella spp., Bordetella spp. etc.), and also acting on mycoplasmas (Mycoplasma gallisepticum, Mycoplasma synoviae, Mycoplasma hyosynoviae, Mycoplasma hyopneumoniae, Mycoplasma meleagridis, Mycoplasma iowae).

Following the parenteral administration, enrofloxacin is rapidly and completely absorbed in animal’s body and distributed in the tissues and 1-2 hours after the administration its active concentration in the tissues and body fluids is several times higher than the concentration in serum.

After the subcutaneous administration of 7.5 mg per 1 kg of the body weight, the maximum plasma concentration amounts to 0.8 μg / ml, this is achieved within 6 hours. Enrofloxacin is partly metabolized in the liver.

Approximately 45% of the administered dose is excreted in the urine and 55% - together with bile in the altered and unaltered form.

INDICATIONS

Cattle, sheep, goats: the treatment of the digestive tract and respiratory system diseases, caused by pathogens susceptible to enrofloxacin.

Pigs: treatment of animals suffering from colybacylos, pasteurellos, mycoplasmos, salmonellos, atrophic rhinitis, enzootic pneumonia syndrome MMA (mastitis-metritis-ahalaktiya) caused by organisms susceptible to enrofloxacin.

Dogs and cats: treatment of animals for diseases of the alimentary canal, respiratory and genitourinary systems, and also skin diseases and external hearing aid, wound infections caused by organisms susceptible to enrofloxacin.

DOSAGE

Subcutaneously at the following doses:

Cattle, sheep, goats: 2.5 ml per 100 kg of body weight, once in a day (2.5 mg of enrofloxacin per 1 kg of body weight);

Intramuscularly:

Pigs: 2.5 ml per 100 kg of body weight, once in a day (2.5 mg of enrofloxacin per 1 kg of body weight);

dogs, cats - 0.5 ml per 10 kg of body weight, once a day

The preparation is used with intervals 24 hours, treatment course 3 - 5 days.

Maximum of 10ml - for cattle, 2.5ml - for piglets and 5ml - adult pigs can be injected at the same site.

CONTRAINDICATIONS

Hypersensitivity to enrofloxacin.
Do not use in dogs less than 12 months old, and in large dog breeds - in their first 18 months of life, pregnant bitches and sows during lactation.
Do not use in animals with diseases in central nervous system or musculoskeletal system, or damages in articular cartilage.
Do not use concurrently with tetracycline preparations, macrolides (erythromycin), chloramphenicol, theophylline.
Do not use simultaneously with immunosuppressive cyclosporine or analogs thereof.
Enrofloxacin should not be used for prevention.

PRECAUTIONS

Do not use if resistant strains of pathogenic bacteria resistant to quinolones was detected.
Animals may only be slaughtered for meat after 12 from the last treatment, and mild can be used after 4 days.

HOW SUPPLIED

Neutral glass vials of 10-mL, 20-mL, 50-mL,100-mL and 200 mL, closed by a rubber stopper and sealed with an aluminum cover. Secondary package: carton box.

STORAGE

Dry, dark, inaccessible to children place at temperature from 5°C to 25°C.
Shelf life - 2 years.
Once opened – it should be stored at 0°C - 5°C and used within 14 days.

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