-500x500.jpg "Metacin forte")
DESCRIPTION
Powder from light-yellow to yellow-brown color, with specific odor of the components.
COMPOSITION
PHARMACOLOGICAL PROPERTIES
Metacin forte – it is a combined medication that contains two antibiotics.
Doxycycline – bacteriostatic antibiotic that belongs to the group of tetracyclines. It affects bacteria ribosomes, preventing protein synthesis. The preparation has a wide range of antimicrobial activity against gram-positive and gram-negative bacteria (Staphylococcus spp., Diplococcus pneumonia, Streptococcus spp., Haemophilus influenza, E. coli, Bacillus antracis, Clostridium tetani, Clostridium perfringes, Listeria monocytogens, Pasteurella spp., Bordetella bronchiseptica, Enterobacter spp., Klebsiella spp., Salmonella spp., Shigella spp., Yersinia spp.), and mycoplasmas (Mycoplasma spp.), rickettsia (Rickettsia spp.) and chlamydia (Chlamydia).
Colistin sulfate is an antibiotic belonging to the group of polymyxins which are synthesized by an aerobic spore-forming bacillus Bacillus polymyxa. It acts bactericidally on gram-negative bacteria (such as E. coli, Salmonella spp., Pseudomonas spp.) through binding with phospholipids of the cytoplasmic membrane increasing its permeability for both intracellular and extracellular components this resulting in the destruction of cellular barriers.
Doxycycline is well absorbed after oral administration; its bioavailability is 90%. The presence of food in the digestive tract does not affect the absorption of doxycycline, unlike other tetracyclines. Doxycycline penetrates well into tissues and sites of inflammation, the concentration in the lungs of pigs and calves about two times higher than in plasma. Once it inside the body, doxycycline is absorbed from the digestive tract of poultry 93-100% and it’s rapidly distributed throughout the body. The half-life is: 10-12 hours – dogs, 4 - 9 – cattle, 10 – horses, 7 – pigs, 3 – sheep. Doxycycline penetrates nearly all organs and tissues, but the highest levels found in lung, liver, bile, reproductive organs and the kidneys. At low concentrations doxycycline is detected in cerebrospinal fluid, but its concentration doesn’t reach a therapeutic level. The maximum concentration detected in blood after 2-4 hours, and therapeutic concentration is maintained for 18-24 hours.
Doxycycline hardly metabolized and excreted primarily in the feces as inactive complexes and to a lesser extent in the urine.
Colistin is absorbed in small quantities from the GI tract and, therefore, acts effectively in GI tract diseases. In contrast to low serum and tissue concentrations of colistin, its high and permanent concentrations are already present in different parts of the GI tract. It is excreted mainly in faeces.
INDICATIONS
Calves under 8 weeks old, pigs: treatment of animals suffering from septicemia and respiratory diseases (pneumonia, pleuropneumonia, atrophic rhinit, etc.), gastrointestinal tract diseases (colibacillosis, salmonellosis), caused by microorganisms sensitive to doxycycline and colistin.
Poultry (broilers, replacements and turkeys): treatment of poultry against colibacillosis, salmonella, chlamydia, septicemia and respiratory diseases caused by microorganisms sensitive to doxycycline and colistin.
ADMINISTRATION AND DOSAGE
Orally with drinking water or with feed at the following doses:
Calves (less than 8 weeks old): 1 g per 100 kg of body weight (5 mg of doxycycline and 48000 IU of colistin sulphate per 1 kg of body weight) twice a day with drinking water, feed, milk or milk substitutor for 3-5 days.
Pigs: 2 g per 100 kg of body weight once a day (10 mg of doxycycline and 96000 IU of colistin sulphate per 1 kg of body weight) or 200 grams in 1000 liters of drinking water daily for 3-5 days.
Poultry (broilers, replacements, turkeys): 0.4 – 0.5 g per 10 kg of body weight per day (20-25 mg of doxycycline and 192000-240000 IU of colistin sulphate per 1 kg of body weight a day) or 100 g. per 500-1000 liters of drinking water daily for 5 days.
To prepare the solution, add the required amount of the product into a small container and, stir constantly, pour the drinking water, preferably warm. The resulting concentrate (the ratio of the medication to drinking water is 1:10) should be immediately added to the required quantity of drinking water in accordance with the required amount for individual age categories of poultry. Prepare a fresh solution on a daily basis.