-500x500.jpg "Tiamucol")
DESCRIPTION
COMPOSITION
PHARMACOLOGICAL PROPERTIES
Tiamulin is a bacteriostatic semisynthetic antibiotic of pleuromutylin group, and acts on the ribosomal level, inhibiting protein synthesis in bacteria.
Tiamulin acts on 70S ribosomal levels. The main place of connection with the ribosomes is 0S subunit, and the possible place of connection – in the joints of subunits 50S and 30S. It inhibits the synthesis of microbial protein, creating a biochemically inactive initiative systems, which prevent the growth of the polypeptide chain.
Tiamulin has bacteriostatic effect. It has strong effect against mycoplasma (M. hyopneurnoniae, M. hyosynoviae, M. hyorhinis) and spirochetes (B. hyodysenteriae, B. pilosicoli). Gram-positive aerobes (Staphylococcus spp., Streptococcus spp., Corynebacterium pyogenes), anaerobes (Clostridia spp.), Gram-negative anaerobes (Lawsonia intracellularis, Bacteroides spp., Ma Fusobacterium spp.) and gram-negative aerobes (Actinobacillus pleuropneumoniae, Pasteurella multocida) show high sensitivity in vitro to tiamulin. Tiamulin has little effect against enterobacteria, such as Salmonella spp. or Escherichia coli.
Tiamulin is a bacteriostatic semisynthetic antibiotic of pleuromutilin goup, and acts on the ribosomal level, inhibiting protein synthesis of bacteria.
Colistin sulphate – antibiotic of polymyxin group that synthesizes by aerobic spore-forming rod Bacillus polymyxa. It effects bactericidally on gram-negative bacteria (e.g. E. coli, Salmonella, Pseudomonas), binding to phospholipids of the cytoplasmic membrane, increasing its permeability both internally and of extracellular components, which leads to degradation of cellular barrier interiors.
INDICATIONS
Treatment of pigs, poultry (broilers, replacements, turkeys) suffering from diseases of the gastrointestinal tract and respiratory system caused by pathogens susceptible to tiamulin and colistin.
DOSAGE
Orally in doses:
|
| daily dose | course of treatment |
| Swine - Prevention and treatment of dysentery | 0.4 kg product per 1 ton of feed | 3 – 5 days |
| Swine - prevention of enzootic pneumonia | 0.22 kg of product per 1 ton of feed | 10 days |
| Swine - treatment of enzootic pneumonia | 0.44 kg of product per 1 ton of feed | 5 – 7 days |
| Prevention and treatment of broilers, replacements, turkeys 1 – 3 days of age | 50 g product per 100 liters of drinking water | 1 , 2 , 3 day of life |
| Chicken 4 weeks old | 25 g product per 100 liters of drinking water | 2 – 3 days in a row |
| Replacements and turkeys on the 4, 9 , 16, 20 weeks of age (in the presence of seropositivity) | 25 g product per 100 liters of drinking water | 3 consecutive days in each of mentioned weeks |
| Replacements and turkeys (in the presence of pathological changes and / or clinical signs) | 50 g product per 100 liters of drinking water | monthly for 3 days in a row |
To prepare the solution put the required amount of the medicine into a small container, stir constantly, pour warm water. Prepared in this way concentrate immediately added to the required amount of water according to the norms of required water to certain age groups of poultry. Prepare fresh solution on a daily basis. The shelf life after mixing with feed – 24-36 hours, when dissolved in water – 12 hours.