SETOL-E (Emulsion for Oral Administration)

SETOL-E (Emulsion for Oral Administration)
SETOL-E (Emulsion for Oral Administration)
Ingredients: Vitamin Е, Sodium selenite
Application: oral
Type of formulation: Feed additive

Characters

A milky white colored emulsion; separates into layers when stored; an insignificant precipitate is tolerable.

Composition

1 mL of the emulsion contains (mg):
- Active substances:
Vitamin Е (-tocopherol acetate) – 100.0;
Sodium selenite – 1.0;

Pharmacological Properties

ATCvet Code: QA11J, Other Vitamin Products, Combinations.

The effect of the product is due to the properties of vitamin E and sodium selenite. Vitamin Е takes part in the synthesis of proteins, lipids, and carbohydrates; stabilizes spermiogenesis, the metabolism of unsaturated fatty acids; prevents lipid peroxide oxidation from occurring; prevents peroxide and hydroperoxide compounds from being formed. Tocopherol is incorporated into lipoprotein structure of membranes and ensures thereby their structural and functional stability. It stimulates erythropoiesis, the synthesis of heme which is incorporated into hemoglobin and myoglobin, tissue respiratory enzymes – peroxidases and cytochromes, and catalase which hydrolyzes hydrogen peroxide. Selenium is incorporated into glutathione peroxidase, an important enzyme of an antioxidant protection of the body which destroys not only hydrogen peroxide but also peroxidates which are formed as a result of the oxidation of unsaturated fatty acids. Selenium is a component of selenoproteins such as selenocysteine and selenomethionine which plays a crucial role in thyroid gland functioning. Selenium deficiency causes a decrease in thyroid gland hormone synthesis and may be one of the factors of autoimmune thyroiditis development.

Indications

SETOL-E is indicated in case of hypovitaminosis E, white-muscle disease and myodystrophy, hepatodystrophy and hepatitis in animals; thyroid gland diseases; in case of stress and diseases such as encephalomalacia, myodystrophy, and exudative diathesis in poultry.

Dosage and Administration

Administer orally via drinking water at a dose level of:

Calves, sheep, and goats – 1 mL per 40 kg of body weight for 5-7 days;

Cattle – 1 mL per 80 kg of body weight for 5-7 days;

Poultry, young pigs – 1 mL per 4000 L of drinking water for 5-7 days; and

Chicks (of up to 21 days of age) – 1 mL per 1000 L to 2000 L of drinking water for 3-5 days.

Prior mixing into drinking water, shake the product thoroughly.

In preparing a stock solution, add the product while stirring to drinking water but not vise versa. Prepare the stock solution at a ratio of 1:10 to 1:20; a white-colored emulsion with a characteristic odor is formed.

Contraindications

An excessive level of selenium in the body and feed (alkali disease).

Hypersensitivity to selenium.

Side Effects

None reported if used at the recommended dose levels.

Overdose (Symptoms, Emergency Procedures, Antidotes)

If overdosed, selenium may cause toxic phenomena.

Antidotes: unithiol, sodium thiosulfate, methionine.

Special Precautions for Use

None reported.

Test the product preliminarily in a small number of animals (7 to 8 animals). If no complication during 2 to 3 days, use the product for the entire livestock population.

How Supplied

10-mL, 20-mL, 50-mL, 100-mL, and 200-mL glass vials closed by rubber stoppers and sealed with aluminum caps and 1-L and 5-L polymeric vials.

Storage

Store at a dry place protected from light at a temperature between +5ºС and +25ºС. Keep out of reach of children.
Shelf life is 2 years of the date of manufacture provided the consumer complies with the requirements for shipping, handling, storage, and use of the product.

Write a review