SL-44 (powder for oral administration)

SL-44 (powder for oral administration)
SL-44 (powder for oral administration)
Ingredients: Lincomycin hydrochloride, Spectinomycin hydrochloride
Application: Oral
Type of formulation: Antibiotic

DESCRIPTION

Powder from white to grayish colorwith a specific odor of the components.

COMPOSITION

Each 1 g contains the activeingredients:
spectinomycin hydrochloride (spectinomycin-base) – 22.0 mg;
lincomycin hydrochloride (lincomycin-base) – 22.0 mg;

PHARMACOLOGICAL PROPERTIES

SL - 44 is a combination drugwhich contains two antibiotics.

Lincomycin belongs to thelincosamide group, has a broad spectrum of action, and is active againstgram-positive and gram-negative microorganisms such as: Staphylococcus spp.,Streptococcus spp., Bacillus anthracis, Corynebacterium spp., Actinobacillusspp., Bordetella spp., some species of Nocardis and Actіnomyces spp. Lincomycinis especially active against Serpulina hyodysenteriae and Mycoplasma spp.Lincomycin exerts its antibacterial action by inhibiting RNA-dependent proteinsynthesis by acting on the 50S subunit of the ribosome. If administered orally,the bioavailability of lincomycin is 50%.

Spectinomycin is anaminocyclitol antibiotic. It is active mainly against gram-negative microflora,including E. coli, Pasteurella multocida, Salmonella spp., Clostridium spp.,Erysipelothrix rhusiopathiae, Haemophylus spp., Vibrio spp., as well asМycoplasma spp. Spectinomycin exerts its antibacterial action by binding to the30S bacterial ribosomes and inhibiting the translation of protein synthesis.

The peak plasma concentrationof these antibiotics is achieved 3 to 6 hours after administration. Lincomycinand spectinomycin are excreted unchanged mainly in the urine and faeces.

Lincomycin and spectinomycinhas a synergy effect in vitro against anaerobes in the pathogenesis of swinedysentery.

INDICATIONS

Pigs: Prevention and treatmentof animals suffering from mycoplasmos, colibacillos, salmonellos, dysentery,and other diseases of the gastrointestinal tract and breathing caused bypathogens susceptible to lincomycin and spectinomycin.

Poultry (broilers, Heifer): prevention and treatment of poultry suffering fromchronic respiratory syndrome (CRD) associated with micoplasma, coli infectionand other diseases of the gastrointestinal tract and respiratory system causedby pathogens susceptible to lincomycin and spectinomycin.

DOSAGE

Orally with drinking water orfeed once a day for 5 – 7 days in following doses:

Pigs:

For prevention – 1 kg per 1 ton of feed. For treatment – 2 kg of the preparation per 1 ton of feed.

Poultry (broilers and Heifer):

For prevention – 1 kg per 1 ton of feed.For treatment – 2 kg per 1 ton of feed (1-2 kg per 1000liters of drinking water), whichcorresponds to 2.3 g per 1 kg of body weight.

If necessary the treatment course might be increased to 21 days.
When using the medicine with drinking water it’s prepared to the requisitequantity of drinking water in accordance with water rates for individual agecategories of poultry. Prepare a fresh solution every day.
Shelf life: when mixed with feed – 24-36 hours, when dissolved in water – 24hours.

CONTRAINDICATIONS

Hypersensitivity to lincomycinand spectinomycin
Do not use in animals with impaired renal function.
Do not use for rabbits, hamsters, guinea pigs, horses and ruminants. This canlead to serious disorders of the alimentary canal.
Do not use concurrently with erythromycin.
Do not use in laying hens producing eggsfor human consumption.

PRECAUTIONS

In the process of mixing thepreparation, the personnel should use protective equipment (respirator,gloves).
Test the drug preliminarily ina small number of animals (7 to 8 heads). If no complication during 2 - 3 days,use the drag for the entire livestock population.
Pigs mayonly be slaughtered for meat 3 days after the last treatment.
Poultry mayonly be slaughtered for meat 2 days after the last treatment.

HOW SUPPLIED

Packets or boxes of 1, 10, 20,100g, and 1 or 25 kg.

STORAGE

Dry, dark, inaccessible tochildren place at temperature from 5°C to 25°C.
Shelf life – 2 years.

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