DUEDEX (ear and eye drops)

DESCRIPTION

Transparent solution, colorless to light yellow.

COMPOSITION

1 ml of the product contains the active ingredients:

- Dexamethasone (as dexamethasone sodium phosphate) – 1.0 mg

- Ofloxacin – 3.0 mg

Excipients: sodium thiosulfate, trelon B, sodium chloride, benzalkonium chloride, hydroxypropylmethylcellulose, hydrochloric acid, sodium hydroxide, water for injection.

PHARMACOLOGICAL PROPERTIES

DUODEX ear and eye drops is a combined chemotherapeutic agent that contains a broad-spectrum antibiotic from the fluoroquinolone group (ofloxacin) and a glucocorticosteroid (dexamethasone). It has antibacterial, anti-inflammatory, anti-allergic, and desensitizing properties.

Dexamethasone is a synthetic glucocorticosteroid with strong anti-inflammatory, anti-edematous, anti-allergic, and other hormonal and metabolic effects. Its anti-inflammatory activity is 30 times stronger than natural cortisol and 7-10 times stronger than prednisone. Dexamethasone prevents the development of inflammatory processes, such as redness, swelling, and pain. It inhibits capillary expansion, phagocytosis, stabilizes lysosomal enzymes in leukocyte membranes, suppresses the synthesis of kinins, mitosis, and leukocyte migration, inhibits antibody production, and prevents allergic reactions. It also affects gluconeogenesis and calcium metabolism.

Ofloxacin is a fluoroquinolone antibiotic, active against Gram-negative microorganisms such as Escherichia coli, Salmonella spp., Proteus spp., Shigella spp., Klebsiella spp., Enterobacter spp., Campylobacter spp., Yersinia spp., Pseudomonas aeruginosa, Vibrio spp., Aeromonas spp., Haemophilus spp., Serratia spp., Chlamydia spp. Ofloxacin is also effective against some Gram-positive bacteria, including Staphylococcus spp. (including penicillinase-producing and methicillin-resistant strains), Streptococcus spp., and is moderately effective against Enterococcus faecalis, Pseudomonas spp., and Streptococcus pneumoniae.

Ofloxacin works by inhibiting bacterial DNA gyrase (topoisomerase II), preventing DNA coiling and synthesis.

One significant advantage of this preparation over other local antibiotics is its high permeability in the cornea and anterior chamber of the eye. Ofloxacin has the best ability among fluoroquinolones to penetrate the cornea and anterior chamber of the eye. Its effective concentration in the tear film remains for up to 4 hours after application. After local application in the conjunctival sac, therapeutic concentration is reached within 30-60 minutes. Systemic reabsorption is minimal and clinically insignificant. After a single dose in the ear, the concentration in the bloodstream is 1000 times lower than after oral administration.

INDICATIONS FOR USE

For the treatment of dogs, cats, and small decorative animals (decorative rabbits, hamsters, rats, mice, guinea pigs, parrots, canaries) in cases of acute and chronic inflammation of the eyes and ears, caused by bacterial, chemical, or traumatic factors: conjunctivitis, blepharitis, keratoconjunctivitis, iritis, iridocyclitis, dacryocystitis, keratitis (without epithelial damage), corneal erosions, chlamydia eye infection, eye diseases after trauma, foreign body penetration, or exposure to aggressive compounds. Also, for the treatment of external and middle ear infections, otorrhea, including those caused by foreign interference.

ADMINISTRATION AND DOSAGE

For eye treatment: Instill 1-2 drops into the conjunctival sac 2-4 times a day. In complicated cases, for the first 1-2 days, instill 1-2 drops every 2-3 hours, then continue with the standard dosage.

For ear treatment: Instill 1-4 drops (depending on the animal's weight) into the ear canal 2-3 times a day until inflammation resolves completely.

If there are significant purulent or mucopurulent secretions, perform a preliminary hygienic treatment of the eyes or ears before instilling the medication.

The treatment course lasts 5-10 days until complete recovery.

Do not allow the dropper tip to touch any surface to avoid contamination of the bottle contents.

CONTRAINDICATIONS

Hypersensitivity to the components of the product (including in history).

Glaucoma and corneal ulcers.

Do not use simultaneously with tetracyclines, macrolides, lincosamides, cyclosporins, or chloramphenicol.

Do not apply in cases of viral or fungal eye and ear infections.

Do not use during vaccination periods.

Not for use in horses.

Do not use simultaneously with theophylline, nonsteroidal anti-inflammatory drugs, or products containing magnesium, aluminum, or calcium cations, which can interfere with the absorption of ofloxacin.

Do not use if resistant strains of pathogens are identified.

PRECAUTIONS

Use the product according to the instructions.

When instilling into the eyes, mild local discomfort, irritation, itching, and tearing may occasionally occur, but they resolve quickly. Allergic reactions are rare.

Prolonged use may lead to secondary glaucoma, steroid-induced cataracts, or corneal thinning.

Use with caution in animals younger than 7 days and in pregnant animals.

FORM OF RELEASE

Polymer or glass bottles with a dropper cap, containing 10 or 15 ml, packed in cardboard boxes.

STORAGE

Store in a dry, dark place, out of reach of children and animals, separately from food and feed, at a temperature of 10 to 25°C.

SHELF LIFE

3 years from the date of manufacture.

After the first use, the product should be used within 30 days.

For veterinary use only!