| Ingredients: | Sulfadimidine, Trimethoprim |
| Application: | Oral |
| Type of formulation: | Antibacterial |
Description
Powder from white to grayishcolor, with specific odor of the components.
Composition
Each 1 g contains theactive ingredients:
Sulfadimidine – 200 mg
Trimethoprim – 40 mg
Pharmacological properties
ATC vet classification code QJ01 - antibacterial veterinary medicines for systemic use. QJ01EW03 - the combination of sulfonamides and trimethoprim.
Trimeratinvet is a combined preparation consisting of sulfadimidine and trimethoprim. The action is caused by the action of the abovementioned components, which together reveal synergic effect, and as a result the activity of the preparation is significantly higher than the activity of individually taken components.
Sulfadimidine and trimethoprim in combination acts bactericidally against most gram-positive and gram-negative microorganisms, including: Staphylococcus spp., Streptococcus spp., Salmonella spp., E. coli, Pasteurella spp., Serpulina hyodysenteriae, Corynebacterium spp., Erysipelothrix rhusiopathiae, Eimeria spp., Proteus spp., Listeria spp., Clostridium spp.
The mechanism of action is consistent inhibition of enzymes involved in the synthesis of folic acid, thereby inhibiting the synthesis of thymidine bacterial cell. Sulfadimidine blocks the conversion of para-aminobenzoic acid into dihydrofolic and trimethoprim blocks the conversion of dihydrofolic acid into tetrahydrofolic by inhibition of dihydrofolate reductase.
Sulfadimidine and trimethoprim are well distributed throughout the body and cross the placenta. During the inflammation of the meninges, the concentration of the active ingredients can reach 50% of the concentration in the serum.
Sulfadimidine and trimethoprim are excreted through the kidneys by glomerular filtration and tubular secretion, is metabolized in the liver. Sulfadimidine mainly is acetylated and conjugated with glucuronic acid, trimethoprim is metabolized to oxide and hydroxylated metabolites.
Indications
Treatment of calves, lambs and kid-goats under the age of 3 months, pigs, dogs, cats and poultry (chickens-broilers and replacement chickens) against diseases of the alimentary canal, respiratory and urinary systems, as well as the complications after viral illnesses, postoperative and posttraumatic infections caused by pathogens which are sensitive to trimethoprim and sulfadimidine.
Dosage and administration
Orally, dissolved in drinking water or milk substitutes according to the following doses:Calves (up to 3 months old) – 0.5 g. per 10-20 kg of body weight for 3-5 days.
Lambs and kid-goats (up to 3 months old) – 0.5 g. per 5-10 kg of body weight for 3-5 days.
Pigs – 0.5 g. per 5-10 kg of body weight for 3-5 days.
Dogs and cats – 0.5 g. per 5-10 kg of body weight for 3-5 days.
Poultry (chickens-broilers and replacement chickens) – 1-1.25 g. per 10 kg of body weight or 0.5 kg of the powder per 1000 liters of the drinking water on a daily basis for 4-7 days.In severe cases in poultry, the doses can be increased to 0.75 kg of the powder per 1000 liters of drinking water on daily basis for 4-7 days.
Use it with intervals of 24 hours.
The solution for poultry is prepared in a ratio of at least10 liters of water for 0.5 kg of the powder, and for this it’s necessary to pour 10 liters of drinking water into a capacity and continuously adding small portions of the powder while stirring. Stir until complete powder dissolution. For a more rapid dissolution of the powder – use warm drinking water. The prepared concentrate (drinking water:powder– 0.5:10) should be immediately added to the required amount of drinking water in accordance with the daily giving amount of water for different age categories of birds. Prepare a fresh solution on a daily basis.
contraindications
Hypersensitivity to sulfadimidine and trimethoprim.
Do not apply to animals with impaired liver and kidney function.
Do not use in laying hens producing eggs for human consumption.
Do not use in ruminants with well-developed proventriculus.
Withdrawal period
Animals: 7 days.
Poultry: 2 days.
How supplied
Packets made of polyethylene pellicle or other polymer pellicle of 1, 2, 10, 50, 100, 500 and 1000 g.
Polymeric containers of 100, 500g. and 1kg.
Storage
Dry, dark, inaccessible to children place at temperature from 5°c to 25°c.
Shelf life – 3 years.