ANTIHELM TRIO (tablets for oral use, per 10 kg)

Round tablets, from light yellow to yellow in colour, with a characteristic odour of the ingredients.

1 g of the product contains active substances:

- fenbendazole - 250 mg;

- pyrantel pamoate - 180 mg;

- praziquantel – 62,5 mg.

Excipients: potato starch, calcium stearate, flavouring agent, flavour enhancer, lactose.

ATCvet: QP52, anthelmintic veterinary medicinal products; QP52AA01 – praziquantel; QP52AF02 – pyrantel, combinations.

ANTIHELM TRIO is a combined product containing fenbendazole, pyrantel pamoate and praziquantel. A broad spectrum of anthelmintic action against various stages of development of roundworms and tapeworms in dogs and cats is based on the pharmacological properties of the components of the product.

Fenbendazole (benzimidazole group) inhibits the polymerisation of tubulin proteins into microtubules, resulting in impaired uptake and intracellular transport of nutrients (adenosine triphosphate (ATP)), which causes the death of parasites from exhaustion.

Fenbendazole has a broad‑spectrum anthelmintic activity against nematodes, cestodes, trematodes of the digestive tract and respiratory tract, and also exhibits an ovicidal action (destroys helminth eggs), reduces contamination of pastures and dog walking areas and decreases the risk of reinfestation in animals.

Fenbendazole is often the main treatment for giardiasis in dogs. Fenbendazole interferes with the organisation of microtubules in the parasite cell and interferes with the excretion of cellular waste and the absorption of nutrients. The parasite cells are depleted rather quickly, and the parasite dies.

Fenbendazole does not exhibit cumulative, embryotoxic, mutagenic or allergic effects and belongs to low-toxicity substances.

When administered orally, fenbendazole is absorbed in the digestive tract and penetrates organs and tissues. It is excreted from the body mainly with urine and faeces unchanged or in the form of metabolites.

Pyrantel pamoate (tetrahydropyrimidine group) is active against young and mature nematodes, affects their cholinergic receptors, which leads to irreversible spastic paralysis of parasites. Pyrantel pamoate is almost not absorbed from the intestine and due to this its anthelmintic action is prolonged. It is excreted from the body mainly unchanged (up to 93%) with faeces.

The combination of the active substances fenbendazole and pyrantel, included in the product, has a synergistic action against nematodes in dogs and cats: Toxocara canis, Toxocara cati, Toxascaris leonina, Ancylostoma spp., Uncinaria spp., Trichuris vulpis, as well as against Giardia spp. (protozoa).

Praziquantel - is a derivative of pyrazinisoquinolones, active against cestodes and trematodes in dogs and cats: Taenia spp., Dipylidium caninum, Echinococcus granulosis, Echinococcus multilocularis. Mesocestoides spp., Diphyllobothrium latum, Opisthorchis felineus, Alaria alata.

Praziquantel is absorbed very quickly by the surface of the parasite and spreads throughout its body. Studies in vitro and in vivo prove that praziquantel destroys the outer covering (tegument) of the parasite. This is an almost instantaneous tetanic contraction of the parasite musculature and rapid vacuolisation of the tegument (covering). This rapid contraction is explained by a change in the permeability of the parasite cell membranes to divalent cations, especially calcium. Depolarisation at neuromuscular junctions, impairment of glucose transport and microtubular function in cestodes lead to impaired muscular innervation, paralysis and death of the parasite.

After oral administration, praziquantel is rapidly absorbed almost completely from the digestive tract and reaches the maximum concentration in blood plasma within 1-3 hours. Its bioavailability is about 80%. Praziquantel is metabolised into inactive forms in the liver and excreted in bile. It is eliminated from the body within 48 hours with urine and in a small amount with faeces.

At the recommended doses, the product has no sensitising, embryotoxic or teratogenic effects.

Deworming and prevention in dogs and cats in case of infestation with:

- nematodes (larval, young and mature stages) - Toxocara canis, Toxocara cati (syn. Toxocara mystax), Toxascaris leonina, Ancylostoma spp., Uncinaria spp., Trichuris vulpis, Strongyloides stercoralis;

- cestodes (preimaginal and imaginal stages) - Dipylidium caninum, Taenia spp., Echinococcus spp., Mesocestoides spp.

- trematodes - Opisthorchis felineus, Alaria alata, Pseudamphistomum truncatum, Echinochasmus perfoliatus.

Doses of the product depending on the animal body weight and tablet weight:

The tablets are administered to animals with feed or directly into the mouth. No preliminary starvation diet or special feeding regimen is required.

The tablets may be divided into halves and quarters for animals with a body weight of less than 10 kg.

Therapeutic deworming is carried out as a single administration. If necessary, according to indications, the treatment may be repeated after 10-14 days.

Preventive deworming of animals is carried out once a quarter at the therapeutic dose, as well as before mating and 12-14 days before vaccination.

Hypersensitivity to the components of the product.

Do not use in puppies under 4 weeks of age.

Do not use in kittens under 6 weeks of age.

Do not use in females one week before parturition and for two weeks after parturition.

Do not use in animals suffering from infectious diseases, or in exhausted and weakened animals.

Do not use in animals with impaired renal or hepatic function.

Do not use the product simultaneously with piperazine derivatives, levamisole, organophosphorus compounds and other medicinal products with cholinergic action.

Use the product according to the package leaflet.

The recommended doses must be strictly observed.

No clinical signs of overdose are observed when the product is used at the recommended doses.

The product may be used in females during lactation provided that puppies have reached 4 weeks of age and kittens have reached 6 weeks of age.

When the recommended dose is increased 3–5‑fold in dogs and the product is used for twice the recommended period, no clinical signs of overdose are observed.

Cats are more sensitive, and in case of overdose the following symptoms may occur: depression, vomiting, diarrhoea, which resolve quickly without specific treatment. There are no specific antidotes.

Sachet-type packets containing 1 tablet (0,8 g) packed in a cardboard box of 10 or 20 sachets.

Store in a dry, dark place inaccessible to children and animals at a temperature from 5 to 25 °С.

3 years.