BAKTIOFUR 20% (suspension for injection)

Oily suspension for injections from white to light brown color.

1 ml of the preparation contains active substance:

- free acid of crystalline сeftiofur -200 mg.

ATC vet classification code QJ01 – anti-infective veterinary preparations for system application.

Сeftiofur is a semi-synthetic antibiotic of third generation cephalosporins group. It possesses a wide spectrum of action against gram-positive and gram-negative bacteria (Pasteurella haemolytica (Mannheimia spp.), Escherichia coli, Pasteurella multocida, Haemophilus somnus, Fusobacterium necrophorum and Bacteroides melaninogenicus (Porphyromonas asaccharolytica), Arcanobacterium pyogenes, Fusobacterium necrophorum, Arcanobacterium pyogenes,  Actinobacillus pleuropneumoniae and Streptococcus suis). Сeftiofur inhibits (suppresses) synthesis of cell walls of bacteria, suppressing synthesis of peptidoglycan.

After parenteral administration, сeftiofur is rapidly metabolized into desferalceftiofur, active metabolite. Due to the binding to plasma proteins, active ceftiofur metabolite is concentrated in the site of inflammation.

Maximum concentration of antibiotic in the blood plasma is observed in 12 hours after the preparation administration and remains on the therapeutic level at least 7 days. Сeftiofur is excreted from organism mostly with urine and partially with feces.

Prior to use a vial with the preparation should be thoroughly shaken to homogeneous suspension obtaining and sediment resuspension.

Maximum volume of the preparation for administration into one site must not exceed 30 ml

Do not apply to animals with increased sensitivity to B-lactam antibiotics.

Do not administer intravenously.

Obtained before specified period meat is disposed or fed to non-productive animals, depending on conclusion of veterinary medicine doctor.

Application of the preparation should be based on pathogens sensitivity determination as well as taking into account of local rules of antimicrobial preparations application.

Penicillins and cephalosporins can cause reactions of hypersensitivity after injection, inhaling, ingestion or contact with skin. Hypersensitivity to penicillins can cause cross-reactions to сephaIosporins and on the contrary. Allergic reactions to these substances sometimes can be severe.

When application of the preparation in accordance to the package leaflet, side effects and complications are usually not observed. In particular, cases formation of swelling is possible.

Should avoid of accidental administration of the preparation to a human. In case of accidental injection to a human, consult a doctor immediately showing the package leaflet or the preparation label. Working with the preparation to people with increased sensitivity to B-lactam antibiotics is not recommended.

In case of preparation contact with skin, rinse thoroughly with soap and water. In case of contact with eyes rinse with pure water immediately.

Vials of neutral glass (marks NS-1, NS-2, UPS-1) closed with rubber stoppers under aluminum crimp seal of 10, 20, 50, 100 and 200 ml. Secondary package – cardboard boxes.

Dry, dark, out of the reach of children place at a temperature from 5°C to 25°C.

Shelf life of the preparation while observing the storing conditions in a closed package is 2 years from the date of manufacture.

After first withdrawal from the vial, the preparation should be used within 14 days, under conditions of storing in a dark place at a temperature from 0 °С to 8 °С.

For applications in veterinary medicine!