ACTIVIL-3 (probiotic in the form of feed supplement)

CHARACTERS

A powder.

COMPOSITION

1 g of this probiotic supplement contains:

- Clostridium butyricum - 1*106 CFU/g;

- Bacillus licheniformis - 1*109 CFU/g;

- Bacillus subtilis - 1*109 CFU/g.

Excipients: Dextrin.

PHARMACOLOGICAL PROPERTIES

ACTIVIL-3 belongs to the 4th generation probiotics and contains spore-forming bacteria Bacillus licheniformis, Bacillus subtilis, Clostridium butyricum. ACTIVIL-3 is resistant to exposure to environmental factors such as an aggressive environment of the gastrointestinal tract and antibiotics due to using spore-forming microorganisms.

Bacillus subtilis is a spore-forming bacterium; it inhibits the growth of pathogenic gram-positive and gram-negative bacteria through competitive replacement thereof, while not causing resistance development. It produces lysozyme and peptides with antibiotic properties, as well as a lot of enzymes in the intestines.

Bacillus licheniformis is a spore-forming bacterium; it synthesizes vitamins in the alimentary tract such as vitamin К, riboflavin, folic acid. It promotes to the maintenance of the acid-base balance in the large intestine; produces lactic acid; promotes to nutrient intake. It inhibits the growth of pathogenic microorganisms and stimulates the growth of lactobacteria.

Clostridium butyricum is a spore-forming bacterium, which synthesizes N-butyric acid that is an energy source for enterocyte proliferation and intestinal epithelium restoration. N-butyric acid acts antimicrobially on gram-negative bacteria, in particular, on Escherichia coli, Salmonella sp., Clostridium perfringens.

The symbiosis of these bacteria improves the intestinal microflora state; reduces the risk of bacterial diseases due to the natural replacement of opportunistic pathogenic bacteria, stimulating the growth of lactic-acid bacteria. A high enzymatic activity of these bacteria supports nutrition processes; improves feed digestion and the absorption of useful substances. Due to the stimulation of phagocytic activity of monocytes and neutrophils, enhancement of the functional activity of macrophages, endogenous interferon induction, and the elevation of the blood gamma globulin fraction, a non-specific resistance of the organism is increased.

INDICATIONS FOR USE

ACTIVIL-3 is used for preventive purposes and in the combined therapy for gastrointestinal infections, to normalize the intestinal microflora in dysbacterioses of various origins, to stimulate growth, to improve digestion, to increase the natural resistance of the organism and immunity stress level during and after vaccinations; to protect the animal’s organism against stresses of various natures.

ROUTE OF ADMINISTRATION AND DOSAGE

Administer the medicinal product orally. Dissolve first in a small amount of warm boiled water. Administer a forced manner using a syringe or mix with feed at the following dose levels:

Small-sized dogs, puppies, cats: 1.5 g per animal per day;

Medium-sized dogs: 3.0 g per animal per day;

Large-sized breed dogs: 6.0 g per animal per day.

Use once a day.

Treat for 5 to 7 days; if required, treatment may be extended by a vet.

CONTRAINDICATIONS

Do not combine with medicinal products having disinfecting properties.

PRECAUTIONS

If used in the recommended doses, no adverse reaction is generally observed. Upon appearance of allergic reactions, terminate the use of the medicinal product and use the desensitization therapy.

HOW SUPPLIED

2-g and 5-g polymeric film packs packaged in cartons in the quantity of 10 and 15 packs.

STORAGE

Store at a dry place protected from light at between 5 °С and 25 °С. Keep out of reach of children.

SHELF LIFE

18 months of the date of manufacture.