DORAMAX (solution for injection)
| Ingredients: | Doramectin |
| Application: | Injection |
| Type of formulation: | ANTIPARASITIC |
Description
Oily liquid from colorless to yellowish color.
Composition
1 ml of the
preparation contains active substance:
- doramectin -
10,0 mg.
Auxiliary
substances: ethyloat, butylhydroxyanisole, benzyl alcohol, cotton oil.
Pharmacological properties
АТС vet QP54, endectocides (QP54AA03, doramectin).
Active substance of the preparation is doramectin
― macrocyclic lactone, semisynthetic derivative of avermectins group.
Doramectin demonstrates a wide spectrum of system nematocidal, insecticidal and
acaricidal activity, larvicidal and ovocidal properties. Modulates chloride
ions activity in nervous system of nematodes and arthropods. By binding to
specific receptors increases permeability of synaptic membranes for chloride
ions, leading to blocking of nematodes and arthropods nervous and muscle cells activity,
which leads to paralysis and death of parasites. In mammals, these receptors
are localized only in the central nervous system, and doramectin does not
penetrate through the blood-brain barrier, therefore in recommended doses is
safe for mammals.
In recommended doses, the preparation does not
have mutagenic, teratogenic and embryotoxic effect.
The DORAMAX preparation is easily resorbed from
injection site, has high efficiency and has no negative effect on animals
organism. Pharmacokinetic peculiarities of doramectin provides for preservation
of therapeutic preparation concentrations in animals blood and for a long time
protect from reinvasion. Prolonged action is twice longer in comparison with
other preparations, which contain ivermectin.
Application
Prophylaxis and treatment of cattle, sheep, pigs, cats, dogs, rabbits in
diseases caused by nematodes and ectoparasites:
Cattle:
- by gastrointestinal nematodes (adults and larvae of 4th stage): Ostertagia ostertagi (including inhibited larvaceous
stage), O.lyrata (adults), Haemonchus
ріасеі, Trichostrongylus axeі, T. colubriformis, Cooperia ncophora,
C.pectinata, C.punctata, C.surnabada (syn. memasteri), Nematodirus
spathiger (adults), Bunostomum
phlebotomum, Strongyloides papillosus, Oesophagostomum radiatum, Trichuris
spp (adults).
- by pulmonary helminths (adults and larvae of 4th stage): Dictyocaulus
viviparous;
- by eye worms (sexually matures): Thelazia spp.;
- by subcutaneous gadfly larvae (parasitic stage): Hypoderma
bovis.eye wormsparasitic stage H. lineatum;
- by louses: Haematopinus euresternus, Linognatus
vituli, Solenopotes capillatus;
- by itch mites: Psoroptes bovis, Sarcoptes scabiei.
Also applied for prophylaxis and treatment of diseases caused by gastrointestinal helminths Nematodirus helvetianus, louses Damalinia bovis and itch mites Chorioptes bovis.
The preparation prevents reinvasion of cattle from:
- Ostertagia ostertagi – 35 days;
- Cooperia oncophora – 21 days;
- Dictyocaulus viviparus – 35 days;
- Bunostomum phlebotomum – 22 days;
- Oesophagostomum radialum – 21 days;
- Trichostrongilus axei – 28 days;
- Linognatus vituli – 28 days;
- Psoroptes bovis – 42 days;
- Haemonchus placei – 28 days.
For more efficiency it is recommended to treat commodity livestock with the
preparation when transfer to pastures and for the second time after 8 weeks.
For more efficiency it is recommended to treat commodity livestock with the
preparation when transfer to pastures and for the second time after 8 weeks.
Sheep:
- by gastrointestinal nematodes (adults and larvae of 4th stage): Chabertia ovina (sexually mature stage), Cooperia
curticei (stage L 4), С. oncophorа, Gaigeria pachyсelis,
Haemonchus contortus, Nematodirus battus (stage L 4), Ostertagia (Teledorsagia)
circumcincta (effectively acts on larval stages L4 , even those that naturally insensitive to
benzimidazole derivative preparations), Oesophagostomum columbianum,
Strongyloides papillosus, Trichostrongylus axei, Trichostrongylus
columbiformis,Trichostrongilus vitrinus, Trichuris spp. (sexually
mature stage)
- by itch mites: Psoroptes ovis,
- by pulmonary helminths: Dictyocaulus filaria (adults),
- by gadfly larvae: Oestrus ovis.
Pigs:
- by gastrointestinal nematodes (adults and larvae of 4th stage): Hyostrongylus rubidus, Ascaris suum, Strongyloides ransomi, Oesophagostomum dentatum, Oesophagostomum quadrispinulatum;
- by pulmonary helminths: Metastrongylus
spp. (sexually mature stage only);
- kidney worms: Stephanurus
dentatus (sexually mature stage only);
- by louses: Haematopinus suis;
- by itch mites: Sarcoptes scabiei.
The DORAMAX preparation protects pigs from invasion or reinvasion
concerning Sarcoptes scabiei during 18
days.
Cats and
dogs:
- by fleas: Ctenocephalides;
- by louses: Linognathides spp.,
Heamatopinus canis, Trichodectes canis, Felicola subrostratus;
- by mites: Demodex canis,
Demodex katoi, D.felis, Otodectes cynotis, Dermacentor spp., Rhipicephalus
spp., Ixodes spp., Sarcoptes canis, Neotrombicula
automnalis, Cheyletiella.
Dosing
Cattle: 1 ml of the preparation for
50 kg of body mass (equivalent to 200 mkg /kg), single time, subcutaneously
into the neck area.
Sheep: 1 ml of the preparation for 50 kg of body
mass (equivalent to 200 mkg /kg), single time, intramuscularly; when diseases
caused by Psoroptes ovis (sheep
scab) and Nematodirus battus (sexually
mature stage) – 1 ml of the preparation for 33 kg of body mass (equivalent to
300 mkg/kg), intramuscularly.
Pigs: 1 ml of the for 33 kg of body mass or 0,3 ml/
10 kg of body mass (equivalent to 300 mkg/kg), intramuscularly.
Piglets with body mass to 16 kg and less (table):
|
Body mass of piglets, kg |
Dose, ml |
|
< 4 |
0.1 |
|
5-7 |
0.2 |
|
8-10 |
0.3 |
|
11-13 |
0.4 |
|
14-16 |
0.5 |
Cats
and dogs:
First way – in a mixture with oily solution of vitamins:
To
cats: 1,0 ml of the preparation + 1,0 ml of group B vitamins solution for each
10 kg animal weight into the thigh area. I.e. 0,2 ml of the solutions mixture
for 1 kg of cat's weight.
To
dogs: 1,0 ml of the preparation + 1,0 ml of group B vitamins solution for each
16 kg animal weight into the thigh area. I.e. 0,125 ml of the solutions mixture
for 1 kg of dog's weight.
Second way – net preparation:
To
cats: 1,0 ml of the preparation for each 10 kg of animal weight, once.
To
dogs: 1,0 ml of the preparation for each 16 kg of animal weight, once.
Rabbits: 1,0 ml of the preparation
for 10 kg of weight, i.e. 0,1 ml of the preparation for each kg of body mass.
Prophylaxis is conducted twice a year
in autumn-winter year period with proper animal management. In addition,
vitamin preparations in solutions are also administered.
Contra-indications
Increased sensation
to the preparation
components.
Do not apply the preparation to females during
lactation if milk is used for human consumption!
Do not apply the preparation to pregnant cows
and heifers 60 days prior to calving!
Warning
Slaughter of animals for meat is permitted after last administration of
the preparation: cattle and sheep – after 35 days, pigs – after 28 days.
Obtained before specified period meat is disposed or fed to non-productive
animals, depending on conclusion of veterinary medicine doctor.
Form of presentation
Vials of neutral glass mark NS-1, NS-2, USP-1 closed with rubber stoppers
under aluminum crimp seal of 10; 20; 50; 100; 200 ml. Secondary package –
cardboard box.
Storage
Dry, protected from light
place, at a temperature from 5 to 25 ºС. Separately from fodders and food, out
of the reach of children and animals.
Shelf life
3 years.