-500x500.png "PerFect TRIO Parasite Collar for Dogs")
CHARACTERS
A polymeric
tape with a buckle of various colors with a characteristic odor of the
components. When stored, blushing is possible.
COMPOSITION
- Active substances:
Fipronil – 50,0 mg;
Ivermectin – 12,0 mg;
Pyriproxifen
– 20,0 mg.
- Excipients:
Dimethyl sulfoxide, isopropanol, PVC tape.
PHARMACOLOGICAL PROPERTIES
ATCvet QP53А,
ектопаразитициди, інсектициди і репеленти.
The collar
exerts a pronounced insectoacaricidal effect with respect to both larval and
adult stages of fleas, fluff louses, chewing louses, ticks (Ixodidae and
Sarcoptoidea), intestinal nematodes, and Dirofilaria
larvae in dogs and cats.
PerFect
TRIO Collar is a combination medicinal product containing fipronil, ivermectin,
and pyriproxifen.
Fipronil, (RS)-5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-(trifluoromethylsulfinyl)-1H-pyrazole-3-carbonitrile,
is a phenylpyryrazole derivative with an insecticidal and acaricidal effect..
Fipronil disturbs
the process of the passage of chloride ions in the GABA – dependent receptors
of ectoparasites; neural transmission, and nervous system activity, causing the
death of the arthropodas. It exerts no effect on the central nervous system in
the mammals. Following application to the skin, fipronil is accumulated in the epidermis, hair follicles, and
adipose glands of the animal and has a long-lasting insectoacaricidal contact
effect.
Ivermectin
belongs to the chemical group of macrocyclic lactones. The pharmacological
action of ivermectin consists in that it acts as an agonist of the GABA
(gamma-aminobutyric acid) neurotransmitter in nerve cells and
also binds to glutamate-gated
chloride channels in nerve and muscle cells of invertebrates.
In both cases it blocks the transmission of neuronal signals of the
ectoparasites and nematodes, which are either paralyzed and expelled out of the
body, or they starve.
Pyriproxifen
is a juvenile hormone analog, which, by disturbing the chitin synthesis and
molting processes in larvae, hampers the growth of competent pupae and causes
the death of insects at the preimaginal stages of development this resulting in
the termination of population replenishment at the egg and larva stages,
prevents the sexually mature insects from being occurred on animals and at the
places of keeping them. In adult insects, the medicinal product does not cause
the death but rather causes adult insect sterilization thereby killing in fact
the insect population.
The active
substances of the collar are released gradually from the tape surface to the
animal’s coat ensuring a long-lasting residual activity.
The collar
is toxic to fish and bees.
INDICATIONS FOR USE
Prevention
of and treatment for ectoparasite and endoparasite invasion in dogs:
● Fleas (Ctenocephalides spp., Pulex irritans);
● Fluff
louses (Linognathus setosus);
● Chewing
louses (Trichodectes canis, Felicola
subrostratus);
●
Mosquitoes of three genera: Aedes, Culex,
and Anopheles;
● Ticks in
the family ixodidae, the hard ticks (Ixodes spp., Dermacentor spp., Haemaphysalis
spp., Rhipicephalus spp., Boophilus calcaratus) at the imaginal, nymphal,
and larval stages;
●
Acariformes (Otodectes cynotis, Notoedres
cati, Sarcoptes canis, and
Cheyletiella spp.);
●
Trombidiformes (Demodex canis, D. gatoi,
D. felis);
● Digestive
tract nematodes (Toxocara spp.,
Toxascaris spp., Trichuris vulpis, Uncinaria stenocephala, and Ancylostoma spp.);
● Larvae
(stages L3 and L4 microfilaria) of Dirofilaria
immitis and Dirofilaria repens.
ROUTE OF ADMINISTRATION AND DOSAGE
Take the
collar out of the package and keep at a dry, well-ventilated place out of reach
of children and animals for 30 minutes, then put the collar on the neck of the
animal, fix it so that a gap of between
The collar
should be loose on the neck and should not retard the growth of the animal.
When secured, the properly fitted collar moves freely around the neck.
The
permanent use of the collar ensures the protection of the animal against ticks
for up to 3 months, against insects for up to 4 months, and against helminthes
for up to 2 months.
The action
of the collar against ticks commences 48 hours after the beginning of use;
therefore, the collar is recommended to be put on 2 to 3 days prior to an
expected contact to parasites. If impossible to do so, examine the animal
carefully before putting on the collar to remove any ticks. If the animal is
heavily infested with insects, prior to use, wash the animal with an
insecticidal shampoo and replace the litters or treat them with an insecticidal
agent in accordance with its instructions for use.
CONTRAINDICATIONS
Hypersensitivity
to the components of the medicinal product!
Do not use
in puppies of up to 2 months of age!
Do not use
in debilitated, sick, and starved animals!
Do not use
to treat other animal species.
Do not use
in animals during pregnancy and lactation.
The
medicinal product is not recommended to use in Collies, Shelties, Old English Sheepdogs, and their mixes because of a possible neurotoxic
action of the components!
PRECAUTIONS
In the
event of an individual hypersensitivity of the animal to the collar components
and if any skin irritation signs appear, terminate the use of the collar.
When
handling the medicinal product, the general rules of personal hygiene and
occupational safety and health when handling veterinary medicinal products
should be complied with.
Take off
the collar when washing animals. The action of the collar against parasites
will be renewed within 48 hours after the collar is put on repeatedly. During
this period of time, an additional protection in the form of the PerFect Insectoacaricidal
Spray is recommended to be used.
In the
event of manifestation of allergic reactions in an animal sensitive to the
components of the medicinal product, prescribe antihistaminic agents and
symptomatic treatment.
Do allow
animals wearing the collars to contact small children.
HOW SUPPLIED
A 35±5-cm or
65±5-cm long PVC tape packaged in a PE or PVC film pack. Secondary package:
individual can.
STORAGE
Store in a
closed original package at a dry place separately from feed and food at between
5 °С and 25 °С. Keep out of reach of children.
SHELF LIFE
2 years.