| Ingredients: | lufenuron, praziquantel, moxidectin |
| Application: | orally |
| Type of formulation: | antiparasitic |
DESCRIPTION
Suspension from light brown to light pink color, with a specific odour of components, stratified during storage, with a precipitate.
COMPOSITION
1 ml of suspension contains active ingredients:
- lufenuron - 20 mg,
- praziquantel - 10 mg,
- moxidectin - 0.6 mg.
Excipients: bentonite; xanthan gum; sodium benzoate, propylene glycol, sucrose, flavour, purified water.
PHARMACOLOGICAL PROPERTIES
ATCvet QP53 ectoparasiticides, insecticides and repellents (QP52 anthelmintic veterinary drugs, QP52AA51 praziquantel, QP54AB02 - moxidectin, combinations).
The combination of lufenuron, moxidectin, praziquantel, which are part of PET EVOLUTION suspension, provides the widest possible range of protection in dogs and cats against external parasites: fleas, scabies mites (ear mites, dog scabies, cat scabies), demodicosis, and internal parasites: tapeworms, roundworms, and larval stages of dirofilariasis . Lufenuron is a broad-spectrum insecticide particularly active against fleas of Ctenocephalides spp. and Pulex irritam species. It disrupts the synthesis of chitin, which is the main component of insect exoskeletons, so larvae cannot form a new cuticle during molting and die. Getting into the body of fleas with animal blood, then into their eggs, lufenuron blocks the process of chitin formation, so the larvae die quickly.
Lufenuron prevents the emergence of the next generation of fleas. Lufenuron is rapidly absorbed in the stomach (better absorbed when the stomach is full of food) and slowly excreted, which ensures a high concentration of the compound in the animal's body for a month. Praziquantel is a pyrazine-isoquinol derivative effective against tapeworms and flatworms.
Praziquantel is rapidly absorbed by the surface of the parasite body and spreads throughout its body, causing processes leading to impaired muscle inertia, paralysis and destruction of the parasite's outer cover. Praziquantel is rapidly absorbed in the digestive tract, reaches its maximum concentration in the blood plasma in 1-3 hours, is distributed in the organs and tissues of the animal; binds to blood serum proteins (70-80%), is excreted in the intestines and is excreted from the body within 48 hours, mainly in the urine (up to 80%) and feces. Moxidectin is a second-generation macrocyclic lactone of the milbemycin group, which has a pronounced effect against many external and internal parasites. The mechanism of action of the drug on the parasite's body is that moxidectin stimulates the release of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), which results in blockade of impulse transmission between interneurons and motor excitatory neurons of the parasite's nerve trunk, which leads to paralysis and death of the parasite. The drug is mostly excreted from the body unchanged within 6 weeks. In the recommended doses, the drug has no sensitizing, embryotoxic or teratogenic effects.
INDIATIONS
Prevention and treatment of dogs and cats, puppies and kittens for mixed parasitic diseases caused by:
- fleas: Ctenocephalides spp., Pulex irritans- elimination of adult fleas, eggs and larvae;
- scabies mites: ear mite (Otodectes cynotis), cat scabies- notoedric mange (Notoedres cati), dog scabies-sarcoptic scab (Sarcoptes canis);
- demodicosis (Demodex canis, D. cati, D. gatof);
- tapeworms in the sexual and immature stages: Dipylidium caninum, Taenia spp., Echinococcus gramulosus, Alveococcus multilocularis, Mesocestoides lineatus, Diphyttobothrium latum.
- roundworms of the digestive tract at all stages of development: Toxocara canis, Toxocara cati (Т. mystax), Toxascaris leonine, Ancylostoma spp., Uncinaria spp., Trichuris vulpis.
- Prevention of allergic flea dermatitis (flea allergy dermatitis: FAD).
- Prevention of dirofilariasis (helminths that parasitize the heart and blood vessels of animals, as well as subcutaneous tissue): Dirqfilaria immitis,
D. repens (affects microfilariae (heartworm larvae) of L3 and L4 stages).
POSOLOGY
The drug is administered orally to animals individually, with a small amount of feed or by force on the root of the tongue using a syringe-dispenser in minimal therapeutic doses:
for dogs - 1 ml of the drug per 2 kg of animal body weight (equivalent to 10 mg of lufenuron, 5 mg of praziquantel, 0.3 mg of moxidectin per 1 kg of animal body weight);
for cats - 1 ml of the drug per 1-1.5 kg of animal body weight (equivalent to 13.4-20 mg of lufenuron, 6.7-10 mg of praziquantel, 0.4-0.6 mg of moxidectin per 1 kg of animal body weight).
Shake the vial with the suspension before use!
In the treatment and prevention of flea infestation and flea allergy dermatitis (flea allergy dermatitis: FAD), the drug is administered to dogs and cats once a month, depending on the epizootic situation.
A single application of the suspension prevents re-infection for 4-6 weeks during the entire season of ectoparasite activity.
The antiparasitic effect of the drug begins to manifest itself in 24 hours and reaches its maximum level in 48-72 hours.
Treatments should be carried out no later than 48 hours before the intended walking of the animal in places of possible presence of parasites (parks, squares, forests, places of general walking).
When treating animals against ear mites (otodectosis) and cat scabies, the drug is administered once. Repeated use of the drug may be prescribed 30 days after the first administration, based on the results of laboratory tests (skin scrapings). In the treatment of dogs scabies (sarcoptic mange), the drug is administered twice with an interval of 30 days. Further use of the drug should be based on clinical evaluation and laboratory tests (skin scrapings).
In the treatment of demodicosis, the drug is administered once every 30 days, 3 to 5 times or until two negative laboratory results are obtained to detect different stages of demodex development (skin scrapings: vital and mortal method) with a difference of one month. In more severe cases, treatment with the drug may be extended. Treatment of animals should be carried out in a comprehensive manner with the use of pathogenetic and symptomatic drugs. In case of animals affected by round and/or tapeworms, the drug is administered twice with an interval of 10-14 days.
For the prevention of helminth infection in animals, the drug is administered to animals at a therapeutic dose once every 3 months, as well as 10-14 days before each vaccination.
For the prevention of dirofilariasis (microfilariae of L3 and L4 stages) in regions with low disease burden, the drug should be administered monthly (at least 6 months), starting treatment one month before the start of the mosquito flight season and ending one month after the end of the mosquito flight (spring- summer-autumn period). The drug reduces the number of microfilariae (larvae) circulating in the blood and can be administered to infected animals. The drug does not affect young and mature heartworms.
CONTRAINDICATIONS
Do not administer to animals with known or suspected hypersensitivity to the drug components.
Do not administer to animals with a history of renal and hepatic impairment! Do not administer to emaciated animals and animals with infectious diseases! Do not administer to females during pregnancy and lactation!
Do not administer to puppies and kittens under 6 weeks of age and weighing less than 1.5 kg.
PRECAUTIONS
The drug is well tolerated by dogs with ABCB1 gene mutation (MDR1 -/-). However, in such sensitive breeds (Collie, Bobtail, Sheltie, related breeds and other sensitive dogs), the dosage should be strictly observed and the animals should be treated under the supervision of a veterinarian.
The drug acts on Ixodes ticks only after the parasite is sucked to the skin and drinks blood of animals, so it does not provide full protection against diseases transmitted by ticks (babesiosis, borreliosis, hemobartonellosis, etc.). For complete protection against Ixodes ticks, it is recommended to additionally treat animals with repellents or acaricides.
The possibility of using the drug during pregnancy and lactation is determined by a veterinarian, considering possible risks.
In some animals, there may be disorders of the digestive tract and increased salivation, depression, which disappear spontaneously and do not require the use of medications.
In case of an overdose of the drug, the animal may experience depression, impaired coordination, refusal to feed, vomiting, and digestive tract disorders. In these cases, the animal is prescribed enterosorbents and symptomatic therapy.
Do not administer the drug in combination with other antiparasitic drugs containing macrocyclic lactones (ivermectin, selamectin, doramectin, milbemycin), with piperazine and drugs that inhibit cholinesterase.
When working with the drug, follow the basic rules of hygiene and safety adopted when working with veterinary drugs.
In case of accidental ingestion of the drug by humans, nervous system disorders are possible, so in such cases, you should immediately consult a doctor (have the drug leaflet or label with you).
PACKAGE
5, 10, 15, 20, 30 and 50 ml glass or polymer vials with plastic caps packed in cardboard boxes.
STORAGE
Store the drug in the original package in a dry place protected from light and out of the reach of children and animals at a temperature between 5 and 25˚С. After the first withdrawal from the vial, the drug should be stored in a dark place at a temperature between 5 and 10 °C for 90 days.
SHELF LIFE
18 months.
FOR VETERINARY USE ONLY!