Ciprocol

Ciprocol
Ciprocol
Ingredients: Colistin sulfate, Ciprofloxacin 
Application: Oral
Type of formulation: Antibiotic

DESCRIPTION

Liquid from light-yellow to dark-yellow color, slight sediment may appear.

COMPOSITION

Each1 ml contains the active ingredients:
Ciprofloxacin – 100 mg;
Colistin sulphate – 1 000 000 IU.

PHARMACOLOGICAL PROPERTIES

Ciprocol – is a combined preparation that contains two antibiotics. As a result of the synergy of the active ingredients, the effectiveness of Ciprocol is significantly higher than its individual components.

Ciprofloxacin – is an antibiotic from fluoroquinolones group. It’s active against gram-negative and gram-positive bacteria, especially against Е.coli, Salmonella spp., Shigella spp., Enterobacter spp., Klebsiella spp., Proteus spp., Serratia spp., Camphylobacter spp., Pseudomonas aeruginosa, Yersinia spp., Vibrio spp., Aeromonas spp., Haemophilus spp., to the preparation are also sensitive: Brucella spp., Staphylococcus spp. (including penicillinase-producing and methicillin-resistant strains), Mycoplasma spp., Mycobacterium spp.. The mode of action of ciprofloxacin is the inhibition of bacterial DNA – gyrase (topoisomerase II), thus stopping the process of replication of DNA. 

Colistin is an antibiotic of polimixin group that synthesizes by aerobic spore-forming rod Bacillus polymyxa. It has bactericidal effects on gram-negative (such as E. coli, Salmonella spp., Pseudomonas spp.), binding to phospholipids of the cytoplasmic membrane, increasing its permeability for internal and external cellular components, which leads to destruction of cellular barrier and lysis of bacterial cell.

INDICATIONS

Treatment of poultry (chickens, broilers, turkeys), doves and dogs, that suffers from colibacteriosis, salmonellosis, streptococcus, pasteurellosis, or from chronic respiratory diseases (CRD), diseases of gastrointestinal tract, mixed and secondary infections during viral diseases, caused by microorganisms, susceptible to ciprofloxacin and colistin.

DOSAGE

Orally for 3-5 days at the following doses:

Poultry (chickens, broilers, turkeys) and doves: 0.5-1 ml per 1 liter of drinking water.

Dogs: 0.07-0.1 ml per 10 kg of body weight.

Before the use, shake well the ampoule or vial (canister).
During the treatment period, poultry should receive only the water that consist the medication as the only source of drinking water. A fresh solution should be prepared every 24 hours.
For dogs, the medication can be given individually orally by using a syringe-tube, with a small amount of drinking water.

CONTRAINDICATIONS

Hypersensitivity to ciprofloxacin and colistin.
Do not use in laying hens producing eggs for human consumption.
Do not use concurrently with tetracycline, chloramphenicol, macrolides and cyclosporine due to the possibility of toxicosis.
Do not use together with non-steroidal anti-inflammatory agents, since it might increase the risk of CNS excitation and convulsions.
Do not use together with preparations containing cations Mg2+, Al3+, Ca2+ as it forms bounds with ciprofloxacin and hinder the absorption.
Do not use in animals with liver and kidney violations.
Do not use for dogs of small breeds less than 8 months old, large dog breeds less than 18 months of age, due to the negative effect on the formation of cartilage and bone tissues.

PRECAUTIONS

In recommended doses, side effects are not observed.
In the event of side effects (itching, muscle tremors), then discontinue the use of the medication and desensitizing therapy should be prescribed.
When used together with theophylline (aminophylline) Ciprofloxacin might increase the levels of theophylline in blood.

If used simultaneously with aminoglycosides, cephalosporins of third generation and broad-spectrum penicillins, a synergism may occur against certain bacteria (especially Pseudomonas aeruginosa and other Enterobacteriaceae).

Poultry may only be slaughtered for human consumption after 14 days from the last treatment.
It is not recommended to use the medication in pregnant dogs. The use is permitted only when the pathogen sensitivity to the medication is specified and possible efficacy is prevailing economic losses.

HOW SUPPLIED

Glass ampoules of 0.5 and 1 ml.
Glass vials of 10, 20, 50 and 100 ml. Outer packaging – carton box.
Polymeric canisters of 240 ml or 1 liter.

STORAGE

In dry, dark, inaccessible to children place at the temperature from 5°C to 25°C.
Keep away from food.
Shelf life – 2 years.
After opening, the preparation should be used within 7 days.

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