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TRIMERATINVET ® tablets
| Ingredients: | Sulfadimidine, Trimethoprim |
| Application: | oral |
| Type of formulation: | ANTIBACTERIAL |
Description
White to greyish tablets.
Composition
1 tablet (0,7 g) of the product contains the active substances:
- sulfadimidine – 400,0 mg;
- trimethoprim – 80,0 mg.
Excipients: calcium stearate, potato starch.
Pharmacological Properties
ATCvet classification code QJ01 – antibacterial veterinary medicinal products for systemic use. QJ01EW03 – Sulfadimidine (sulfadimezine) and trimethoprim.
TRIMERATINVET tablets is a combination product containing sulfadimidine and trimethoprim. The action of the product is due to the synergistic effect of its components, as a result of which their combined activity is significantly higher than that of each component taken separately.
Sulfadimidine and trimethoprim act bacteriostatically against most microorganisms, including Gram-positive (Staphylococcus spp., Streptococcus spp., Clostridium spp., Listeria monocytogenes, Corynebacterium spp., Bordetella spp., and others) and Gram-negative (E. coli, Salmonella spp., Klebsiella spp., Proteus spp., Pasteurella spp., and others) microorganisms, as well as protozoa (Toxoplasma spp., Coccidia (Eimeria spp. and Isospora spp.)).
The mechanism of action consists in the sequential inhibition of enzymes involved in folic acid synthesis, thereby suppressing thymidine synthesis in the bacterial cell.
Sulfadimidine is a bacteriostatic sulfonamide of intermediate duration of action. It disrupts the acquisition by microorganisms of growth factors necessary for their development — folic acid and substances whose molecules contain para-aminobenzoic acid. Under the influence of sulfadimidine, the formation of methionine, purine and pyrimidine bases in the microbial cell is impaired, which in turn leads to disruption of nucleic acid and nucleoprotein synthesis.
Trimethoprim is a synthetic antimicrobial agent, a derivative of diaminopyrimidine, active against gram-positive and gram-negative bacteria by blocking the reduction of dihydrofolic acid to tetrahydrofolic acid, which is essential for microbial development.
Sulfadimidine is slowly absorbed from the gastrointestinal tract; maximum blood concentration is reached within 4–6 hours. Plasma protein binding of sulfadimidine varies depending on the animal species: in cattle and pigs — 80%.
Sulfadimidine is primarily acetylated and conjugated with glucuronic acid. The half-life is 7 hours.
The pharmacodynamic and pharmacokinetic properties of trimethoprim are similar to those of long-acting sulfonamides. Trimethoprim is highly stable in an acidic environment, is rapidly absorbed after oral administration, and penetrates all body tissues. Maximum blood concentration is reached within 1–3 hours after administration and is maintained for 7 hours. High concentrations are achieved in the lungs and kidneys. Trimethoprim is metabolised in the liver to oxide and hydroxylated metabolites. The half-life is 8–10 hours.
Sulfadimidine and trimethoprim are excreted via the kidneys by glomerular filtration and tubular secretion, and are metabolised in the liver. Sulfadimidine is primarily acetylated and conjugated with glucuronic acid; trimethoprim is metabolised to oxide and hydroxylated metabolites.
Indications
Calves up to 3 months of age: treatment of animals affected by colibacillosis, pasteurellosis, salmonellosis, bronchopneumonia, and abscesses caused by microorganisms susceptible to trimethoprim and sulfadimidine.
Pigs: treatment of animals affected by pneumonia, atrophic rhinitis, salmonellosis, haemophilus pleuropneumonia, colibacillosis, pasteurellosis, and eimeriosis caused by microorganisms susceptible to trimethoprim and sulfadimidine.
Dogs and cats: treatment of animals affected by bordetellosis (infectious tracheobronchitis), salmonellosis, endometritis, cystitis, rhinitis, and abscesses caused by microorganisms susceptible to trimethoprim and sulfadimidine.
Dosage and Administration
Administer orally, dissolved in water or milk, or mixed with feed, at the following doses:
- pigs, calves – 1 tablet per 15–20 kg body weight (25 mg sulfadimidine per 1 kg body weight and 5 mg trimethoprim per 1 kg body weight) once daily for 3–5 days;
- dogs, cats – 1 tablet per 15–20 kg body weight (25 mg sulfadimidine per 1 kg body weight and 5 mg trimethoprim per 1 kg body weight) once daily for 3–5 days.
Contraindications
Hypersensitivity to sulfadimidine and trimethoprim or to any of the excipients.
Do not use in animals with impaired hepatic or renal function, or in cases of blood dyscrasia.
Do not use in lactating animals.
Do not use in ruminants with functionally developed forestomachs.
Concurrent use with B-group vitamins (nicotinamide, folic acid, choline), with procaine, benzocaine (anaesthesine), or other para-aminobenzoic acid derivatives is prohibited due to their antagonistic interaction with sulfonamides.
Precautions
Adverse reactions
In isolated cases (in animals hypersensitive to sulfadimidine and trimethoprim), allergic reactions may occur (skin rash, pruritus, and oedema).
Special precautions for use
Do not use in severely dehydrated animals. If allergic reactions occur, discontinue treatment.
Use of the product should be based on susceptibility testing of the causative microorganisms to sulfadimidine and trimethoprim. If this is not possible, treatment should be based on local (regional, farm-level) epizootic information on the susceptibility of target bacteria.
Use during pregnancy, lactation and laying
Use in pregnant animals is not recommended due to the potential adverse effect on foetal development. Use is permitted only when it is evident that the benefits of treatment outweigh the potential risks, according to the benefit/risk assessment by the responsible veterinarian.
Do not use in lactating animals.
Interactions with other medicinal products and other forms of interaction
Antacids used concurrently with this product may reduce its bioavailability.
Withdrawal period
Slaughter of animals for meat is permitted 10 days after the last administration of the product. Meat obtained prior to this period must be disposed of or fed to non-productive animals, depending on the decision of a veterinarian.
Presentation
Blister packs of 1 and 10 tablets; polymer containers of 27 and 270 tablets.
Storage
Store in a dry, dark place, out of reach of children, at a temperature of 5 to 25 °C.
Shelf life
3 years.
For veterinary use only!