PNEUVOSEPT (powder for oral administration)

Ingredients:	Spectinomycin hydrochloride, Lincomycin hydrochloride, Florfenicol
Application:	oral
Type of formulation:	antibiotic

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Description
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DESCRIPTION

Powder from white to grayish color with specific odor of the components.

COMPOSITION

Each 1 g contains the active substance:

- spectinomycin hydrochloride (spectinomycin-base) - 22.0 mg;

- lincomycin hydrochloride (lincomycin-base) - 22.0 mg;

- florfenicol - 50.0 mg.

PHARMACOLOGICAL PROPERTIES

Pneumosept is a combined preparation containing three antibiotics.

Lincomycin - a lincosamide antibiotic. It acts on Gram-positive organisms such as: Staphylococcus spp., Streptococcus spp., Bacillus anthracis, Corynebacterium spp., some types Nocardis spp. and Actinomyces spp. Especially effective against Serpulina hyodysenteriae and Mycoplasma spp. Lincomycin is inhibition of protein synthesis at the ribosomal subunit 50S.

Spectinomycin – amino-cyclic antibiotic. Acting primarily on Gram-negative bacteria, including Е. coli, Pasteurella multocida, Salmonella spp., Clostridium spp., Erysipelothrix rhusiopathiae, Haemophylus spp., Vibrio spp.,, And Mycoplasma spp.. Spectinomycin cause inhibition of protein synthesis at the level of ribosomal subunit 30S.

Lincomycin and spectinomycin act synergistically in vitro against anaerobes in the pathogenesis of swine dysentery.

Florfenicol – from group fenicoles group antibiotic, active against gram-negative and gram-positive bacteria, including: Staphylococcus spp., Streptococcus spp., Enterobacter spp., E. coli, Pasteurella haemolytica, Pasteurella multocida, Pasteurella piscicida, Vibrio spp., Haemophilus somnus, Haemophilus parasuis, Fusobacterium necrophorum, Bacteroides melaninogenicus, A. pleuropneumoniae, Bordetella bronchiseptica, Salmonella spp., Klebsiella spp., Proteus spp., Shigella spp. and others).

The mechanism of florfenicol action is to bound with 70S ribosomes and blocking protein synthesis in the bacterial cell.

INDICATIONS

Pigs: treatment of animals suffering from mycoplasmosis, eperitrozoonozom, lavsoniozami, syndrome of mastitis-metritis-agalactia, colibacillosis, salmonellosis, dysentery, pleuropneumonia, atrophic rhinitis disease Glessera (gemofileznogo polyserositis), pasteurellosis, as well as in diseases of the digestive tract and breathing caused microorganisms sensitive to lincomycin, spectinomycin and florfenicol.

Poultry (broilers, rearing poultry): the treatment of poultry with chronic respiratory syndrome (CRD), associated with Mycoplasma, colibacillosis, pasteurellosis, mycoplasmosis, salmonellosis and in diseases of the respiratory and digestive tract caused by microorganisms sensitive to lincomycin, spectinomycin and florfenicol.

DOSAGE

Oral dosage with feed 1 once daily at the following doses:

- pigs - 2 kg per 1 ton of feed for 5-7 days;

- poultry (broilers and rearing) - 2 kg per 1 ton of feed for 5-7 days.

CONTRAINDICATIONS

Hypersensitivity to lincomycin, spectinomycin and florfenicol.

Do not use in animals with impaired renal function.

Do not use rabbits, hamsters, guinea pigs, horses and ruminants. This can lead to serious disorders of the digestive canal.

Do not use concurrently with erythromycin.

Do not use in hens which eggs are intended for use in human food.

It is not recommended to use in pregnant sows since it might cause a negative effect on the formation of cartilage in the fetus.

Do not use concurrently with thiamphenicol or chloramphenicol, antibiotics from penicillin group, cephalosporins, fluoroquinolones and sulfonamides drugs.

PRECAUTIONS

During mixing with feed must always use personal protection equipment (respirator, gloves). Slaughtering of animals and poultry for meat is permitted in 14 days (pigs) and 7 days (poultry) after the last treatment.

HOW SUPPLIED

Packages or polymeric containers or cans of 1, 2, 10, 20, 50, 100 and 500 g, 1 and 25 kg.