Doramax (solution for injection)

Doramax  (solution for injection)
Doramax (solution for injection)
Ingredients: Doramectin
Application: Injection
Type of formulation: ANTIPARASITIC


Description

Oily liquid from colorless to yellowish color.
 

Composition

1 ml of the preparation contains active substance:
doramectin - 10,0 mg.
Auxiliary substances: ethyloat, butylhydroxyanisole, benzyl alcohol, cotton oil.
 

Pharmacological properties

АТС vet  QP54, endectocides (QP54AA03, doramectin)
Active substance of the preparation is doramectin ― macrocyclic lactone, semisynthetic derivative of avermectins group. Doramectin demonstrates a wide spectrum of system nematocidal, insecticidal and acaricidal activity, larvicidal and ovocidal properties. Modulates chloride ions activity in nervous system of nematodes and arthropods. By binding to specific receptors increases permeability of synaptic membranes for chloride ions, leading to blocking of nematodes and arthropods nervous and muscle cells activity, which leads to paralysis and death of parasites. In mammals, these receptors are localized only in the central nervous system, and doramectin does not penetrate through the blood-brain barrier, therefore in recommended doses is safe for mammals.
In recommended doses, the preparation does not have mutagenic, teratogenic and embryotoxic effect.
The DORAMAX preparation is easily resorbed from injection site, has high efficiency and has no negative effect on animals organism. Pharmacokinetic peculiarities of doramectin provides for preservation of therapeutic preparation concentrations in animals blood and for a long time protect from reinvasion. Prolonged action is twice longer in comparison with other preparations, which contain ivermectin.
 

Application

Prophylaxis and treatment of cattle, sheep, pigs, cats, dogs, rabbits in diseases caused by nematodes and ectoparasites:
Cattle:
by gastrointestinal nematodes (adults and larvae of 4th stage):
Ostertagia ostertagi (including inhibited larvaceous stage), O.lyrata (adults), Haemonchus ріасеі, Trichostrongylus axeі, T. colubriformis, Cooperia ncophora, C.pectinata, C.punctata, C.surnabada  (syn. memasteri), Nematodirus spathiger (adults), Bunostomum phlebotomum, Strongyloides papillosus, Oesophagostomum radiatum, Trichuris spp (adults).
by pulmonary helminths (adults and larvae of 4th stage): Dictyocaulus viviparous;
by eye worms (sexually matures): Thelazia spp.;
by subcutaneous gadfly larvae (parasitic stage): Hypoderma bovis.eye wormsparasitic stage H. lineatum;
by louses: Haematopinus euresternus, Linognatus vituli, Solenopotes capillatus;
by itch mites: Psoroptes bovis, Sarcoptes scabiei.
Also applied for prophylaxis and treatment of diseases caused by gastrointestinal helminths
Also applied for prophylaxis and treatment of diseases caused by gastrointestinal helminths Nematodirus helvetianus, louses Damalinia bovis and itch mites Chorioptes bovis.
The preparation prevents reinvasion of cattle from:
The preparation prevents reinvasion of cattle from:
Ostertagia ostertagi – 35 days;
Cooperia oncophora – 21 days;
Dictyocaulus viviparus – 35 days;
Bunostomum phlebotomum – 22 days;
Oesophagostomum radialum – 21 days;
Trichostrongilus axei – 28 days;
Linognatus vituli – 28 days;
Psoroptes bovis – 42 days;
Haemonchus placei – 28 days.
For more efficiency it is recommended to treat commodity livestock with the preparation when transfer to pastures and for the second time after 8 weeks.
For more efficiency it is recommended to treat commodity livestock with the preparation when transfer to pastures and for the second time after 8 weeks.
Sheep:
by gastrointestinal nematodes (adults and larvae of 4th stage):
Chabertia ovina (sexually mature stage), Cooperia curticei (stage L 4), С. oncophorа, Gaigeria pachyсelis, Haemonchus contortus, Nematodirus battus (stage L 4), Ostertagia (Teledorsagia) circumcincta (effectively acts on larval stages L4 , even those that naturally insensitive to benzimidazole derivative preparations), Oesophagostomum columbianum, Strongyloides papillosus, Trichostrongylus axei, Trichostrongylus columbiformis, Trichostrongilus vitrinus, Trichuris spp. (sexually mature stage)
by itch mites: Psoroptes ovis,
by pulmonary helminths: Dictyocaulus filaria (adults),
by gadfly larvae: Oestrus ovis.
Pigs:
by gastrointestinal nematodes (adults and larvae of 4th stage):
Hyostrongylus rubidus, Ascaris suum, Strongyloides ransomi, Oesophagostomum dentatum,
Oesophagostomum quadrispinulatum;
by pulmonary helminths:   Metastrongylus   spp. (sexually mature stage only);
kidney worms:  Stephanurus   dentatus (sexually mature stage only);
by louses: Haematopinus suis;
by itch mites:  Sarcoptes scabiei.
The DORAMAX preparation protects pigs from invasion or reinvasion concerning Sarcoptes scabiei during 18 days.
Cats and dogs:
by fleas: Ctenocephalides;
by louses: Linognathides spp., Heamatopinus canis, Trichodectes canis, Felicola subrostratus;
by mites:  Demodex canis, Demodex katoi, D.felis, Otodectes cynotis, Dermacentor spp., Rhipicephalus spp., Ixodes spp., Sarcoptes canis, Neotrombicula automnalis, Cheyletiella.
 

Dosing

Cattle: 1 ml of the preparation for 50 kg of body mass (equivalent to 200 mkg /kg), single time, subcutaneously into the neck area.
Sheep: 1 ml of the preparation for 50 kg of body mass (equivalent to 200 mkg /kg), single time, intramuscularly; when diseases caused by Psoroptes ovis (sheep scab) and Nematodirus battus (sexually mature stage) – 1 ml of the preparation for 33 kg of body mass (equivalent to 300 mkg/kg), intramuscularly.
Pigs: 1 ml of the for 33 kg of body mass or 0,3 ml/ 10 kg of body mass (equivalent to 300 mkg/kg), intramuscularly.
Piglets with body mass to 16 kg and less (table):
 

Body mass of piglets, kg

Dose, ml

< 4

0.1

5-7

0.2

8-10

0.3

11-13

0.4

14-16

0.5

Cats and dogs:
First way – in a mixture with oily solution of vitamins:
To cats: 1,0 ml of the preparation + 1,0 ml of group B vitamins solution for each 10 kg animal weight into the thigh area. I.e. 0,2 ml of the solutions mixture for 1 kg of cat's weight.
To dogs: 1,0 ml of the preparation + 1,0 ml of group B vitamins solution for each 16 kg animal weight into the thigh area. I.e. 0,125 ml of the solutions mixture for 1 kg of dog's weight.
Second way – net preparation:
To cats: 1,0 ml of the preparation for each 10 kg of animal weight, once.
To dogs: 1,0 ml of the preparation for each 16 kg of animal weight, once.
Rabbits: 1,0 ml of the preparation for 10 kg of weight, i.e. 0,1 ml of the preparation for each kg of body mass.
Prophylaxis is conducted twice a year in autumn-winter year period with proper animal management. In addition, vitamin preparations in solutions are also administered.
 

Contra-indications

Increased sensation to the preparation components.                
Do not apply the preparation to females during lactation if milk is used for human consumption!
Do not apply the preparation to pregnant cows and heifers 60 days prior to calving!
 

Warning

Slaughter of animals for meat is permitted after last administration of the preparation: cattle and sheep – after 35 days, pigs – after 28 days.
Obtained before specified period meat is disposed or fed to non-productive animals, depending on conclusion of veterinary medicine doctor.

Form of presentation

Vials of neutral glass mark NS-1, NS-2, USP-1 closed with rubber stoppers under aluminum crimp seal of 10; 20; 50; 100; 200 ml. Secondary package – cardboard box.

Storage

Dry, protected from light place, at a temperature from 5 to 25 ºС. Separately from fodders and food, out of the reach of children and animals.

Shelf life

3 years.

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