TYLOCYCLINVET ® (powder for oral use)

TYLOCYCLINVET ® (powder for oral use)
TYLOCYCLINVET ® (powder for oral use)
Ingredients: Doxycycline hyclate, Tilosin tartrate 
Application: Oral
Type of formulation: Antibiotic
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DESCRIPTION

Powder from light-yellow to dark-yellow color, with light specific odor.

COMPOSITION

Each 1 g contains the active ingredients:
- doxycycline hyclate – 100 mg
- tilosin tartrate – 100 mg.

PHARMACOLOGICAL PROPERTIES

ATC vet classification code QJ01 - antibacterial veterinary medicines for systemic use. QJ01RA90 - tetracyclines, combination with other antimicrobial agents.

Tilocyclinvet – a combinated preparation consisting of doxycyclin and tylosin.

Doxycyclin – bacteriostatic antibiotic that belongs to the group of tetracyclines. It affects the ribosome of bacteria, preventing protein synthesis. The preparation has a wide range of antimicrobial activity against gram-positive and gram-negative bacteria (Staphylococcus spp., Diplococcus pneumonia, Streptococcus spp., Haemophilus influenza, E. coli, Pneumococci, Bacillus antracis, Clostridium tetani, Clostridium perfringes, Listeria monocytogens, Actinomyces spp., Entirobacter spp ., Klebsiella spp., Salmonella spp., Shigella spp., Yersinia spp.), and mycoplasmas (Mycoplasma spp.), rickettsia (Rickettsia spp.) and chlamydia (Chlamydia).

Tylosin – macrolide antibiotic, active against gram-negative and gram-positive microorganisms (Staphylococcus spp., Streptococcus spp., Diplococcus spp., Corynebacterium spp., Clostridium spp., Erysipelothrix rhusiopathiae, Neisseria spp., Bacteriodes nodosus, Moraxella bovis, Pasteurella spp., Spirocheta spp.). Particularly sensitive to tylosin are mycoplasmas (Mycoplasma gallisepticum, Mycoplasma hyopneumoniae, Mycoplasma synoviae, Mycoplasma meleagridis, Mycoplasma agalactiae, Mycoplasma bovigenitalium), and chlamydia (Chlamydia) and rickettsia (Rickettsia spp.).

Mechanism of action of tylosin is to block protein synthesis in bacterial cells by forming a complex with the 50S-ribosome subunits. Resistance to it in microorganisms occurs fairly quickly.

INDICATIONS

Calves, kid-goats and lambs (from 4 to 8 weeks old), pigs: treatment of animals suffering from septicemia and respiratory diseases (bronchopneumonia, enzootic pneumonia, atrophic rhinitis, etc.), gastrointestinal tract (colybacylosis, salmonellosis), which are caused by pathogens susceptible to doxycycline and tylosin.

Young chickens, broilers, turkeys: treatment of poultry from colybacylosis, salmonella, chlamydia, septicemia and respiratory diseases caused by microorganisms sensitive to doxycycline and tylosin.

DOSAGE

Orally with drinking water or feed for 3-5 days:

- pigs – 1 g per 1 liter of drinking water (or 1 g per 10 kg of body weight) daily;

- calves, lambs, kid-goats (from 4 to 8 weeks old) – 1 g per 10 kg of body weight once a day.

- poultry (chickens, broilers, turkeys) – 1 g per 1 liter of drinking water, every day.

The first dose can be increased twice depending on disease severity.

CONTRAINDICATION

Hypersensitivity to preparations tetracycline and tylosin.
Do not use for ruminant animals with functionally developed pre-stomachs and for laying hens, whose eggs will be used for human consumption.
Do not use in animals with impaired liver and kidney.
Do not use concurrently with antibiotics cephalosporins and lincomycin, as they reduce the antibacterial effect.
Do not use with unsterile anti-inflammatory agents.

PRECAUTIONS

Pigs and poultry may only be slaughtered for meat after 8 days from the last treatment; calves, lambs, goats after 14 days.

HOW SUPPLIED

Packets made of polyethylene pellicle of 1, 50, 100, 500 and 1000g.
Containers of 100, 500g and 1 kg.

STORAGE

Dry, dark, inaccessible to children place at temperature from 5°C to 25°C.

Shelf life 

2 years.

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