TURYL 2,5% (solution for oral use)
| Ingredients: | Toltrazuril |
| Application: | oral |
| Type of formulation: | COCCIDIOSTATIC |
Description
Liquid from colorless to brownish-yellowish
color, opalescence is permissible.
Composition
1 ml of the
preparation contains active substance:
- toltrazuril
- 25 mg.
Auxiliary
substances: triethanolamine, polyethyleneglycol.
Pharmacological properties
ATCvet QP51, antiprotozal veterinary preparations
(QP51AJ01, toltrazuril).
Active substance of
the preparation toltrazuril (symmetrical triazinetrione) – effective
eimeriostat.
Toltrazuril
disturbs intracellular stages of eimeria development, affecting on meronts,
micro- and macrogametes. Disturbs the process of nuclear fission of eimeria and
decreases activity of mitochondria responsible for respiratory metabolism.
After oral
administration of the preparation, toltrazuril is slowly absorbed in alimentary
tract of poultry. In organism of animals toltrazuril is partially metabolized
with forming of sulfoxide-and sulphon derivatives. Further – almost completely
excreted with feces in unchanged form or in the form of toltrazurilsulphon or
toltrazurilsulfoxide.
The
preparation has no mutagenic, carcinogenic and teratogenic action.
Application
Treatment of hens (broiler chicken, replacement chickens), turkeys at
eimeriosis caused by eimeria sensitive to toltrazuril:
- in hens: Eimeria acervulina, E. brunetti, E. maxima, E.
mitis, E. necatrix, E. tenella;
- in turkeys: Eimeria adenoides, E. meleagridis, E.
meleagrimitis.
Dosing
Before application the preparation is thoroughly mixed with drinking
water and fed to poultry during 2 days at a dose of 7 mg of toltrazuril for 1
kg of body mass (28 ml of the preparation for 100 kg of poultry body mass) per
day which corresponds to daily preparation application calculated as 1 ml of
the preparation for 1 l of drinking water when feeding during 24 hours or 3 ml
of the preparation for 1 l of water when feeding during 8 hours per day two
weeks in a row.
In case of sediment appearance, the solution prior to use should be
thoroughly shaken.
For effective treatment the preparation is recommended to apply to
poultry before clinical signs of disease arising – during incubation period.
Contra-indications
Increased sensation to toltrazuril!
Is not applied to laying hens, eggs of which are intended for use for
human consumption!
Warning
Slaughter of poultry for meat is permitted in 5 days after last
application of the preparation. Obtained before specified period meat is
disposed or fed to non-productive animals, depending on conclusion of
veterinary medicine doctor.
Personnel dealing with the preparation must adhere to the general rules
of hygiene and safety adopted when working with veterinary preparations. In
case of accidental contact of the preparation with skin or eyes rinse with
water immediately. During working with the preparation smoking, drinking and
eating is prohibited.
Form of presentation
Vials of neutral glass mark NS-1, NS-2, USP-1 or polymeric of 100, 200
ml.
Containers (vials) polymeric according to TU U 23455985-001 of 1 l. Polymeric
canisters of 5 l.
Storage
Dry, dark, out of the reach of
children place at a temperature from 5°C to 25°C. After first withdrawal from
the vial the preparation should be used within 3 months, under conditions of
storing in a dark place at a temperature from 5 to 25 °С.
Shelf life
24 months from date of manufacture.