| Ingredients: | levofloxacin, colistin sulfate, lactic acid, purified water |
| Application: | Oral |
| Type of formulation: | antibacterial |
Description
Oily solution from the yellow to yellowish brown
color, with a characteristic odor of constituent components, light
precipitation is allowed.
Composition
1 ml of product contains the following active
ingredients:
levofloxacin – 150.0 mg
colistin sulfate – 1,200,000 IU.
Inactive ingredients: lactic acid, purified water.
Pharmacological properties
АТС vet
classification code QJ01 - antibacterial veterinary medicines for systemic use.
ORNITIL is a combined medicine
consisting of levofloxacin and colistin sulphate. As a result of the synergetic effect
of the active ingredients, the efficiency of the product is significantly
higher than that of its individual components.
Levofloxacin
is a fluoroquinolone antibiotic, ofloxacin levoisomer, active against
gram-negative and gram-positive microorganisms, especially against Е.coli, Enterobacter spp., Klebsiella spp.,
Proteus spp., Serratia spp., Camphylobacter spp., Pseudomonas aeruginosa,
Yersinia spp. , Vibrio spp., Aeromonas spp., Haemophilus spp., the
following microorganisms are also susceptible to the product: Brucella spp., Chlamydia trachomatis,
Legionella pneumophilia, Moraxilla catarrhalis, Campylobacter spp., Salmonella
spp., Shigella spp., Staphylococcus spp. (including penicillinase-producing
and methicillin-resistant strains), Streptococcus
spp., Mycoplasma spp., Mycobacterium spp., Peptostreptococcus spp.
The mechanism of
action of levofloxacin involves suppression of bacterial DNA gyrase (type II
topoisomerase), which thus stops the DNA helimerization and synthesis process.
Colistin is a
polymyxin antibiotic. It provides bactericidal effect on gram-negative bacteria
(E. coli, Salmonella spp., Pseudomonas
spp.) by contacting with the phospholipids of the cytoplasmic membrane,
increasing its permeability for both intra- and extra-cellular components,
resulting in degradation of the cell wall of bacteria.
Levofloxacin is
rapidly and almost completely absorbed after oral administration. Feed has
little effect on the speed and fullness of absorption. The bioavailability of
levofloxacin after oral administration is nearly 100%. The half-life of
levofloxacin is 6-8 hours.
Colistin is
absorbed in a small amount from the digestive tract, thus effective in diseases
of the digestive tract. In contrast to the low colistin concentrations in serum
and tissues, its high and constant concentrations are always present in the
various parts of the digestive tract. There is a large colistin concentration
in the cecum and colon. It is mainly excreted with feces.
Application
Dogs: treatment
of animals suffering from septicemia, arthritis, polyarthritis, meningitis,
mastitis, dermatitis, secondary infections in viral diseases, as well as in
diseases of the respiratory organs (tonsillitis, tracheitis, pneumonia,
bronchitis, rhinitis, sinusitis, bronchial pneumonia), gastrointestinal tract
(gastritis, enteritis, peritonitis), genitourinary system (nephritis, pyelitis,
pyelonephritis, urethritis, metritis, urocystitis) caused by microorganisms
susceptible to levofloxacin and colistin.
Pigeons: treatment of birds for diseases of the respiratory and gastrointestinal tract, caused by microorganisms susceptible to levofloxacin and colistin
Dosage
Oral administration within 24 hours with the following
doses:
Pigeons – with drinking water, 0.5 ml of the product
per 1 l of drinking water;
Dogs - with drinking water or liquid feed, 0.25 ml of
the product per 10 kg of the animal’s body weight.
Treatment course - 3-5 days.
Before using shake the ampoule or vial containing the
product thoroughly.
During treatment, pigeons should receive water
containing the product only. Daily prepare a fresh solution of the product in
the amount designed for consumption during the day.
Dogs can be individually administered the product
orally through a syringe with a small amount of drinking water.
Counterindications
Hypersensitivity to levofloxacin and colistin.
Do not administer to animals with impaired renal and
hepatic function.
Do not administer concurrently with tetracyclines,
macrolides, lincosamides, chloramphenicol or non-steroidal anti-inflammatory
agents.
Do not use concurrently with drugs containing cations
Mg2 +, Al3 +, Ca2 +.
Do not administer to dogs of small breeds less than 8
months of age, large breeds - less than 18 months of age due to the negative
impact on the formation of cartilage and bone tissue.
Do not administer to animals during pregnancy.
Do not administer to productive animals.
Precautions
At the recommended doses, no adverse effects are
usually observed. In the event of adverse events (pruritus, nausea, vomiting,
muscle tremors) stop using the product, apply desensitizing therapy.
Pharmaceutical form
Grade NS-1, NS-2, USP-1 neutral glass 0.5 and 1 ml
ampoules.
Grade NS-1, NS-2, USP-1 neutral glass 2, 5, 10, 20,
50,100 and 200 ml vials.
Secondary package - cardboard box.
240 ml polymeric containers (vials).
Storage
Dry dark, in a place inaccessible to children at a
temperature from 5 °C to 25 °C.
Shelf life - 2 years.
After the first extraction from the vial, the product
must be used within 14 days when stored in a dark place at a temperature from 4
°C to 8 °C.