Boviken (solution for injection)

 Boviken (solution for injection)
Boviken (solution for injection)
Ingredients: Marbofloxacin, Ketoprofen
Application: injecting
Type of formulation: Antibacterial


Liquid from light-yellow to dark-yellow color.


Each 1 mL contains the active ingredients:
Marbofloxacin – 40 mg.
Ketoprofen – 60 mg.


The active ingredients of the drug are: Marbofloxacin - an antibiotic, which belongs to the group of fluoroquinolones, and Ketoprofen - a non-steroidal anti-inflammatory agent.

Marbofloxacin active against gram-negative and gram-positive bacteria, and particularly against: Staphylococcus spp., Escherichia coli, Salmonella typhimurium, Citrobacter freundii, Enterobacter cloacae, Serratia marcescens, Morganella morganii, Proteus spp., Klebsiella spp., Shigella spp., Pasteurella spp., Haemophilus spp., Moraxella spp., Pseudomonas spp.), and against the mycoplasma (Mycoplasma bovis, Mycoplasma hyopneumoniae(.

The mechanism of its action is the inhibition of bacterial DNA-gyrase (topoisomerase II), thus the stops the process of helix and synthesis of DNA.

After the administration, Marbofloxacin rapidly absorbed, reaching its peak concentration in plasma of 1.5 mg / ml in less than 1 hour. The bioavailability is close to 100%. Marbofloxacin weakly bound to plasma proteins (less than 10% in pigs and 30% in cattle), well distributed in most tissues (liver, kidney, skin, lung, uterus), it reaches a higher concentration than in plasma. Marbofloxacin slowly excreted in calves (t1 / 2 = 5-9 hours) and pigs (t1 / 2 = 8-10 hours), faster in ruminant animals (t1 / 2 = 4-7 hours), primarily in active form the urine and feces.

Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) of the propionic acid class.

Ketoprofen exerts three main pharmacological effects which are common to all NSAIDs: antiinflammatory, analgesic and antipyretic. The primary mechanism of action is inhibition of prostaglandin synthesis through interference with the cyclo-oxygenase pathway of arachidonic acid metabolism. Also, ketoprofen has been shown to inhibit lipooxygenase, to have an anti-bradykinin activity, to stabilize lysosomal membranes, and to cause a significant inhibition of neutrophil activity. Ketoprofen is a double inhibitor of inflammation through blocking the pathways of action of cycloxygenase and lipoxygenase thereby preventing prostaglandins and leukotrienes from being produced.

Ketoprofen is an analgetic, which exerts effect on the central nervous system and the peripheral nervous system. Its action is to inhibit directly the action of bradykinin, a vasodilatator and pain mediator.

Ketoprofen is absorbed quickly. Over 98% bind to plasma proteins and are accumulated in inflamed tissues. Ketoprofen metabolizes in the liver into insignificant biologically active metabolites and 90% are excreted with the urine in the form of glucuronide compounds.


Used in cattle and pigs for the treatment of respiratory diseases that are accompanied by pain, inflammation or fever and caused by susceptible strains of microorganisms )Pasteurella multocida, Mannheimia haemolytica, Mycoplasma bovis, Actinobacillus pleuropneumoniae, Mycoplasma hyopneumoniae(; and in cows - for treatment against mastitis caused by E.coli; Treatment of sows with MMA syndrome (mastitis-metritis-agalactia).


Intramuscularly, 0.5 ml per 10 kg of body weight, once a day, for 3 days (equivalent to 2mg of marbofloxacin and 3 mg of ketoprofen per 1 kg of body weight).


Do not use in animals with hypersensitivity to marbofloxacin or ketoprofen.
Do not use in animals with heavy infringements of renal and hepatic functions, and animals with lesions of the central nervous system.
Do not use if the quinolone-resistant strains of pathogenic microorganisms was detected.
Not used in conjunction with diuretics, anticoagulants and nephrotoxic agents, well as with other non-steroidal anti-inflammatory agents.
Do not use simultaneously with tetracycline drugs, erythromycin, chloramphenicol, theophylline.


Cattle may only be slaughtered for human consumption after 7 days and pigs – 4 days from the last treatment. Consumption of milk is permitted after 4 days.


Neutral glass vials of 10-mL, 20-mL, 50-mL or 100-mL, closed by a rubber stopper and sealed with an aluminum cover. Secondary package: carton box.


In a dark, dry place, at 5°C - 25°C.
Shelf life: 2 years.
Shelf life after the first selection of the vial for 14 days under aseptic condition and subsequent storage of the container with the drug at a temperature of 10°C to 15°C

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